How tumor mechanics and tiny messengers could shape the future of cancer research
A literature review co-written by Penn Engineering Ph.D. student Kshitiz Parihar and Ravi Radhakrishnan, professor in bioengineering and chemical biomolecular engineering, highlights the hidden connections between tumor mechanics and extracellular vesicles (EVs), tiny packages of proteins and genetic material secreted by cells. EVs carry cargo like proteins and RNA between cells, influencing how tumors grow, how the immune system responds, and even how cancers spread to other parts of the body. The researchers hypothesize that both that the surrounding tissue environment affects the vesicles and that the process is reciprocal. “We’re seeing that vesicles don’t just respond to the environment,” Radhakrishnan says. “They actively reshape it. They can stiffen tissue and prime it for metastasis.”
Novel plant-based approach to a better, cheaper GLP-1 delivery system
Research led by Penn Dental’s Henry Daniell investigates the use of a lettuce-based, plant-encapsulated delivery platform as a new oral delivery of two GLP-1 drugs previously approved by the FDA in injectable form.
No brain, no gain: Neuronal activity enhances benefits of exercise
Research led by Penn neuroscientist J. Nicholas Betley and collaborators finds that hypothalamic neurons are essential for translating physical exertion into endurance, potentially opening the door to exercise-mimicking therapies.
In honor of Valentine's Day, and as a way of fostering community in her Shakespeare in Love course, Becky Friedman took her students to the University Club for lunch one class period. They talked about the movie "Shakespeare in Love," as part of a broader conversation on how Shakespeare's works are adapted.
In Becky Friedman’s English course Shakespeare in Love, undergraduate students analyze language, genre, and adaptation in the Bard’s plays through the lens of love.
Beating the heat: Designing cooling for bodies in motion
Dorit Aviv, director of Weitzman’s Thermal Architecture Lab, studies how humans, technology, and design intersect, paving the way for the development of novel approaches to cooling people efficiently.
