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Penn Researchers Tame the Inflammatory Response in Kidney Dialysis

Penn Researchers Tame the Inflammatory Response in Kidney Dialysis

Frequent kidney dialysis is essential for the approximately 350,000 end-stage renal disease (ESRD) patients in the United States. But it can also cause systemic inflammation, leading to complications such as cardiovascular disease and anemia, and patients who rely on the therapy have a five-year survival rate of only 35 percent.

Karen Kreeger

Simeprevir-Based Therapy Offers Alternative Treatment of Hepatitis C Says Penn Study

Simeprevir-Based Therapy Offers Alternative Treatment of Hepatitis C Says Penn Study

Researchers at Penn Medicine, in collaboration with a multi-center international team, have shown that a protease inhibitor, simeprevir, a once a day pill, along with interferon and ribavirin has proven as effective in treating chronic Hepatitis C virus infection (HCV) as telaprevir with interferon and ribavirin, the standard of care in developing countries.

Lee-Ann Donegan

Penn Study: Majority of Women with Early-Stage Breast Cancer in U.S. Receive Unnecessarily Long Courses of Radiation

Penn Study: Majority of Women with Early-Stage Breast Cancer in U.S. Receive Unnecessarily Long Courses of Radiation

Two-thirds of women treated for early-stage breast cancer in the U.S. receive longer radiation therapy than necessary, according to a new study published in JAMA this week from Penn Medicineresearchers Ezekiel J. Emanuel, MD, PhD, and Justin E. Bekelman, MD.

Steve Graff

Penn Medicine Researchers Announce Latest Results of Investigational Cellular Therapy CTL019

Penn Medicine Researchers Announce Latest Results of Investigational Cellular Therapy CTL019

The latest results of clinical trials of more than 125 patients testing an investigational personalized cellular therapy known as CTL019 will be presented by a University of Pennsylvania research team at the 56th American Society of Hematology Annual Meeting and Exposition.

Holly Auer

Brain Activity after Smokers Quit Predicts Chances of Relapsing, Penn Medicine Study Suggests

Brain Activity after Smokers Quit Predicts Chances of Relapsing, Penn Medicine Study Suggests

Quitting smoking sets off a series of changes in the brain that Penn Medicine researchers say may better identify smokers who will start smoking again—a prediction that goes above and beyond today’s clinical or behavioral tools for assessing relapse risk.

Steve Graff

Penn Study Points to New Therapeutic Strategy in Chronic Kidney Disease

Penn Study Points to New Therapeutic Strategy in Chronic Kidney Disease

Chronic kidney disease (CKD) affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease’s progress towards kidney failure.

Karen Kreeger

Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts’ Brain Function

Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts’ Brain Function

Space is one of the most demanding and unforgiving environments. Human exploration of space requires astronauts to maintain consistently high levels of cognitive performance to ensure mission safety and success, and prevent potential errors and accidents.

Greg Richter

Penn Researchers Identify Protein Elevated in Blood That Predicts Post-Concussion Symptom Severity in Professional Athletes

Penn Researchers Identify Protein Elevated in Blood That Predicts Post-Concussion Symptom Severity in Professional Athletes

New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes.

Lee-Ann Donegan

Penn Researchers Unwind the Mysteries of the Cellular Clock

Penn Researchers Unwind the Mysteries of the Cellular Clock

Human existence is basically circadian. Most of us wake in the morning, sleep in the evening, and eat in between. Body temperature, metabolism, and hormone levels all fluctuate throughout the day, and it is increasingly clear that disruption of those cycles can lead to metabolic disease.

Karen Kreeger