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20 breakthroughs of 2025
Masoud Akbarzadeh holding up one of the fabricated materials.

The Polyhedral Structures Laboratory is housed at the Pennovation Center and brings together designers, engineers, and computer scientists to reimagine the built world. Using graphic statics, a method where forces are mapped as lines, they design forms that balance compression and tension. These result in structures that use far fewer materials while remaining strong and efficient.

(Image: Eric Sucar)

20 breakthroughs of 2025

From ancient tombs and tiny robots to personalized gene editing and AI weather models, Penn’s 2025 research portfolio showed how curiosity—paired with collaboration—moves knowledge into impact and stretches across disciplines and continents.
Addressing the psychological impacts of inflammatory bowel disease
Therapist and patient.

Image: lorenzoantonucci via Getty Images

Addressing the psychological impacts of inflammatory bowel disease

In a collaborative study, Psychologist Melissa Hunt and gastroenterologist Chung Sang Tse showed that cognitive behavioral therapy reduced disability for patients with Crohn’s disease and ulcerative colitis and that psychologists with no prior gastrointestinal experience could learn to deliver IBD-informed CBT effectively.

3 min. read

Evolution at a molecular level

Biologist Mia Levine and colleagues have demonstrated how a pair of essential protein partners undergo rapid evolutionary change to counter fast-evolving parasitic DNA while maintaining core cellular functions. The work presents novel insight into how evolution works at the molecular level.

(Image: Getty images/Joao Paulo Burini)

Evolution at a molecular level

Research led by Mia Levine shows how a vital DNA protection protein complex adapts to new threats without compromising essential functions.

3 min. read

An opportunity to do more to help victims of violence

An opportunity to do more to help victims of violence

The Penn Trauma Violence Recovery Program at the Penn Injury Science Center received new Pennsylvania funding to help victims rebuild their lives interrupted by violence.

Startup recognized for milestones in cancer care
Marco Ruella in the Ruella Lab, collaborating with two lab technicians. Ruella is wearing a white lab coat and holding up a chemical sample. Two of his colleagues are observing the sample.

Marco Ruella, associate professor of medicine at PSOM and hematologist-oncologist at Penn Medicine, collaborates with his colleagues in the Ruella Lab.

nocred

Startup recognized for milestones in cancer care

During the Penn Center for Innovation’s 10th annual Celebration of Innovation, viTToria Biotherapeutics was presented with the Startup of the Year Award for its remarkable progress in the development of promising treatment of T-cell lymphoma.

4 min. read

Early immune clues could help detect and prevent type 1 diabetes
A teen takes a blood sugar reading with an app on their phone.

Image: Halfpoint Images via Getty Images

Early immune clues could help detect and prevent type 1 diabetes

Researchers from Penn Medicine have uncovered new clues in pancreas lymph nodes and the spleen that may stop the disease before insulin is lost forever.

Matt Toal

2 min. read