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‘Leukemia-on-a-chip’ could transform CAR T blood cancer treatments
The actual chip of human leukemia bone marrow where chambers and channels were filled with food dyes.

The actual chip of human leukemia bone marrow where chambers and channels were filled with food dyes.

(Image: NYU Tandon Applied Micro-Bioengineering Laboratory/Courtesy of Weiqiang Chen)

‘Leukemia-on-a-chip’ could transform CAR T blood cancer treatments

In a collaborative effort with NYU, Penn researchers have helped pioneer a novel 3D platform that mimics the human bone marrow and immune environment, enabling more predictive testing of cancer immunotherapy success in patients, including CAR T cell therapies.

3 min. read

Red Ribbon Connect links Penn with HIV/AIDS researchers worldwide
Timethius Terrell standing upright in a bright outdoor setting, while smiling and facing forward.

Timethius Terrell serves as program lead for Red Ribbon Connect. He’s dedicated to promoting global collaboration in HIV/AIDS research.

(Image: Elliot Sipila)

Red Ribbon Connect links Penn with HIV/AIDS researchers worldwide

Organized by a recent Penn alum on the Community Advisory Board of the Penn Center for AIDS Research, the newly launched Red Ribbon Connect program entails a monthly virtual exchange for HIV/AIDS researchers at Penn and worldwide to swap insights and perspectives.

5 min. read

Food insecurity linked to elevated mortality risk among cancer survivors

Food insecurity linked to elevated mortality risk among cancer survivors

A new study from the Perelman School of Medicine shows that cancer survivors experiencing food insecurity had a 28 percent relative increase in risk of death versus those who were food secure.

Eric Horvath

1 min. read

Gene therapy may slow loss of motor function in ALS
A microscopic rendering of a neuromuscular junction.

Image: Koto_Feja via Getty Images

Gene therapy may slow loss of motor function in ALS

Researchers at the Perelman School of Medicine and Children's Hospital of Philadelphia used RNA interference to silence a key protein that causes ALS, showing promise for treating the devastating neurodegenerative disease.

Kelsey Geesler

Penn Medicine outreach addresses health-related social needs
A volunteer with Penn Medicine SHARE Food Program hands a box of food to a bike courier.

Image: Courtesy of Penn Medicine Magazine

Penn Medicine outreach addresses health-related social needs

For five years, Penn Medicine’s Social Needs Response Team has connected patients to vital support foundational to good health.

From Penn Medicine Magazine

2 min. read

Nancy A. Speck honored for pioneering research in hematology

Nancy A. Speck honored for pioneering research in hematology

Speck, the John W. Eckman Professor in Medical Science II and chair of the department of Cell and Developmental Biology in the Perelman School of Medicine, has been named the 2025 recipient of the E. Donnall Thomas Lecture and Prize from the American Society of Hematology.

Decoding ancient immunity networks
Hand holding a blood vial that reads "complement (C3 + C4)"

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the body’s bouncer, “deciding” which foreign materials get degraded by immune cells and which are allowed entry.

(Image / iStock Md Saiful Islam Khan)

Decoding ancient immunity networks

A collaborative team from Penn Medicine and Penn Engineering have  unraveled the mathematics of a 500-million-year-old protein network that “decides” which foreign materials are friend or foe.

Nathi Magubane , Ian Scheffler , Holly Wojcik , Matt Toal

5 min. read

New chair of Orthopaedics starts a new chapter in a lifetime of service
Benjamin Potter holding a piece of prosthetic hardware.

Benjamin “Kyle” Potter demonstrates how the OPRA implant (Integrum LLC), which is FDA-approved for osseointegration following transfemoral amputation, fits into the AXOR II failsafe device, directly linking a patient's residual bone to an external prosthesis.

(Image: Courtesy of Penn Medicine News)

New chair of Orthopaedics starts a new chapter in a lifetime of service

Following a distinguished military career, Benjamin ‘Kyle’ Potter is bringing his battle-tested expertise to Penn.

From Penn Medicine News

2 min. read

What can ants and naked-mole rats teach about societal roles?
Leafcutter ants moving around a bright green leaf.

In eusocial superorganisms like leafcutter ant colonies, labor is divvied up according to body shape and size, but PIK Professor Shelley Berger and her team discovered that molecular signals can override that blueprint. Their findings reveal how simple neuropeptides can reprogram ant behavior, reshuffling roles in nature’s most disciplined workforce.

(Image: Courtesy of Tierney Scarpa)

What can ants and naked-mole rats teach about societal roles?

PIK Professor Shelley Berger and colleagues explored the genetic basis of labor distribution in communal-dwelling species and discovered that pathways dating back hundreds of millions of years are conserved across animal kingdoms. Their findings offer fundamental insights into complex social behaviors.

5 min. read