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Armoring CAR T cells to take on cancer
3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read

Veterinary student on the human benefits of poultry medicine
Dana Bubka.

Dana Bubka, an aspiring diagnostic poultry veterinarian, has been doing clinical rotations at New Bolton Center leading up to her graduation in May from the School of Veterinary Medicine.

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Veterinary student on the human benefits of poultry medicine

Dana Bubka came to the School of Veterinary Medicine knowing she wanted to be a poultry veterinarian, and after graduation, she is staying at Penn for a residency in anatomic pathology.

4 min. read

How climate change impacts food security
A panel of speakers seated at Perry World House.

Image: Courtesy of Perry World House

How climate change impacts food security

Perry World House’s “Feeding a Climate-Changed World” conference brought together climate experts to discuss democracy, human rights, and the geopolitics of food security.

2 min. read

Advanced robotic imaging helps Rusty the therapy horse avoid surgery
A young rider on Rusty the horse.

Rusty, a 20-year-old Quarter Horse, helps riders with physical and cognitive disabilities build strength, confidence, and independence Thorncroft Equestrian Center. State-of-the-art robotic imaging at Penn’s New Bolton Center was key to Rusty’s diagnosis and treatment when he developed lameness in his leg.

(Image: Ryan Sansom)

Advanced robotic imaging helps Rusty the therapy horse avoid surgery

When Rusty, a 20-year-old therapy Quarter Horse, developed lameness in his right hind leg, his diagnosis required advanced imaging. Unlike traditional CT scanners, New Bolton Center’s robotic imaging was key to Rusty’s diagnosis and treatment when he developed lameness in his leg.

Sacha Adorno

2 min. read

New genetic cause of blindness in dogs
Aguirre and Murgiano working in a lab with pipettes.

Gustavo D. Aguirre and Leonardo Murgiano of the School of Veterinary Medicine of the University of Pennsylvania.

(Image: John Donges)

New genetic cause of blindness in dogs

In collaboration with a foundation that breeds service dogs for the visually impaired, researchers at the School of Veterinary Medicine at the University of Pennsylvania and the University of Padova in Padova, Italy, have identified a novel variant associated with progressive retinal atrophy in three Labrador retrievers.

3 min. read

Avian influenza experts from Penn provide briefing to Pennsylvania policymakers

Avian influenza experts from Penn provide briefing to Pennsylvania policymakers

Experts from Penn’s School of Veterinary Medicine and Perelman School of Medicine visited the Pennsylvania State Capitol to brief the General Assembly on the University’s response efforts to the highly pathogenic avian influenza outbreak.

One tiny dog’s outsized contribution to brain surgery
A dog with a bandage on their head.

Geddy following her surgery.

(Image: Courtesy of Penn Vet News)

One tiny dog’s outsized contribution to brain surgery

A terrier mix makes history as the first patient to undergo canine neurosurgery in a collaborative effort of specialists in human and veterinary medicine using cutting-edge augmented reality technology and infrared imaging.

Sacha Adorno

Balancing renewable energy development and land protection
Jonathan Thompson, Andrew M. Hoffman, and Grace Wu on stage.

University of Pennsylvania School of Veterinary Medicine Dean Andrew M. Hoffman, center, moderated a discussion with Jonathan Thompson and Grace Wu on tradeoffs in land use for renewable energy.

(Image: Ashley Hinton/Penn Vet)

Balancing renewable energy development and land protection

In an Energy Week event, Grace Wu and Jonathan Thompson provided perspectives on tradeoffs in land use from their work in California and Massachusetts.