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Improving T-cell responses to vaccines
Person in mask holding vaccine vial.

Image: franckreporter via Getty Images

Improving T-cell responses to vaccines

Penn Vet and Penn Medicine researchers have modified mRNA vaccines to include the cytokine IL-12 and improve T-cell responses which could improve the body’s ability to fight infections.

3 min. read

Determining the cause of cryopreservation fertility failures
Spermatogenesis at a microscopic level

Image: Ed Reschke via Getty Images

Determining the cause of cryopreservation fertility failures

A new study from Penn’s School of Veterinary Medicine on germ cell gene regulatory networks offers a holistic understanding of complex male germ cell differentiation in meiosis and spermatogenesis.

Martin Hackett

2 min. read

New tools to treat retinal degenerations at advanced stages of disease
Raghavi Sudharsan and William Beltran by a microscope in a lab.

Raghavi Sudharsan and William Beltran of the Division of Experimental Retinal Therapies at Penn’s School of Veterinary Medicine.

nocred

New tools to treat retinal degenerations at advanced stages of disease

A collaborative team of researchers led by vision scientists at the School of Veterinary Medicine have developed novel promoters that drive strong and specific gene expression in rod and cone photoreceptors in mid-to-late stages of disease, potentially offering new and improved options for gene therapy.

3 min. read

Promising inhibitor combination for hard-to-treat leukemia subtypes
Andres Blanco in a lab at Penn Vet.

Andrés Blanco is an assistant professor of biomedical science at Penn’s School of Veterinary Medicine.

(Image: John Donges)

Promising inhibitor combination for hard-to-treat leukemia subtypes

Researchers from Penn Vet and other institutions have identified a novel inhibitor combination of molecules that induce terminal differentiation for the treatment of human non-APL subtypes of AML.

From Penn Vet

2 min. read

Penn breaks ground on Gail P. Riepe Center for Advanced Veterinary Education
Eight people on stage with shovels for ceremonial groundbreaking.

The University of Pennsylvania and School of Veterinary Medicine community celebrated the groundbreaking of the Gail P. Riepe Center for Advanced Veterinary Education. (Left to right:) Scarlett Loya, Amy Durham, J. Larry Jameson, Jim Riepe, Gail Riepe, Andrew M. Hoffman, Robert Marookian, and Barbara Dallap Schaer.

(Image: Lisa Godfrey)

Penn breaks ground on Gail P. Riepe Center for Advanced Veterinary Education

A gift from Penn alumni Gail and Jim Riepe will support the construction of the 11,800-square-foot facility at Penn Vet’s New Bolton Center campus.

3 min. read

Armoring CAR T cells to take on cancer
3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read

Veterinary student on the human benefits of poultry medicine
Dana Bubka.

Dana Bubka, an aspiring diagnostic poultry veterinarian, has been doing clinical rotations at New Bolton Center leading up to her graduation in May from the School of Veterinary Medicine.

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Veterinary student on the human benefits of poultry medicine

Dana Bubka came to the School of Veterinary Medicine knowing she wanted to be a poultry veterinarian, and after graduation, she is staying at Penn for a residency in anatomic pathology.

4 min. read

How climate change impacts food security
A panel of speakers seated at Perry World House.

Image: Courtesy of Perry World House

How climate change impacts food security

Perry World House’s “Feeding a Climate-Changed World” conference brought together climate experts to discuss democracy, human rights, and the geopolitics of food security.

2 min. read

Advanced robotic imaging helps Rusty the therapy horse avoid surgery
A young rider on Rusty the horse.

Rusty, a 20-year-old Quarter Horse, helps riders with physical and cognitive disabilities build strength, confidence, and independence Thorncroft Equestrian Center. State-of-the-art robotic imaging at Penn’s New Bolton Center was key to Rusty’s diagnosis and treatment when he developed lameness in his leg.

(Image: Ryan Sansom)

Advanced robotic imaging helps Rusty the therapy horse avoid surgery

When Rusty, a 20-year-old therapy Quarter Horse, developed lameness in his right hind leg, his diagnosis required advanced imaging. Unlike traditional CT scanners, New Bolton Center’s robotic imaging was key to Rusty’s diagnosis and treatment when he developed lameness in his leg.

Sacha Adorno

2 min. read

New genetic cause of blindness in dogs
Aguirre and Murgiano working in a lab with pipettes.

Gustavo D. Aguirre and Leonardo Murgiano of the School of Veterinary Medicine of the University of Pennsylvania.

(Image: John Donges)

New genetic cause of blindness in dogs

In collaboration with a foundation that breeds service dogs for the visually impaired, researchers at the School of Veterinary Medicine at the University of Pennsylvania and the University of Padova in Padova, Italy, have identified a novel variant associated with progressive retinal atrophy in three Labrador retrievers.

3 min. read