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New Penn Vet study uncovers a key guardian of gut health and metabolism
Oriol Sunyer pointing to rainbow trout, the fish species used for the reported study.

Oriol Sunyer pointing to rainbow trout, the fish species used for the reported study.

Image: Courtesy of Penn Vet

New Penn Vet study uncovers a key guardian of gut health and metabolism

Researchers at the School of Veterinary Medicine unveil the critical role of secretory immunoglobulin M (sIgM) in maintaining microbiota balance, regulating metabolism, and protecting against disease.

Martin Hackett

2 min. read

Informing Pennsylvania public health and safety on deer ticks
A tiny deer tick in the palm of a hand.

Ticks are active when the temperature is above freezing, but their activity intensifies during the warmer months. Late-spring and summer are peak Lyme season, with the highest transmission occurring between May and August.

(Image: Olga Pankova)

Informing Pennsylvania public health and safety on deer ticks

A study of deer and ticks at the Penn’s School of Veterinary Medicine could shape public health and safety across the Commonwealth.

From Penn Vet

2 min. read

Keeping food safe and animals healthy
A lab technician injecting small eggs with a substance via syringe.

nocred

Keeping food safe and animals healthy

As part of the Pennsylvania Animal Diagnostic Laboratory System (PADLS), Penn Vet’s New Bolton Center helps to protect animals and humans from health threats and minimize agricultural economic loss.

7 min. read

Improving T-cell responses to vaccines
Person in mask holding vaccine vial.

Image: franckreporter via Getty Images

Improving T-cell responses to vaccines

Penn Vet and Penn Medicine researchers have modified mRNA vaccines to include the cytokine IL-12 and improve T-cell responses which could improve the body’s ability to fight infections.

3 min. read

Determining the cause of cryopreservation fertility failures
Spermatogenesis at a microscopic level

Image: Ed Reschke via Getty Images

Determining the cause of cryopreservation fertility failures

A new study from Penn’s School of Veterinary Medicine on germ cell gene regulatory networks offers a holistic understanding of complex male germ cell differentiation in meiosis and spermatogenesis.

Martin Hackett

2 min. read

New tools to treat retinal degenerations at advanced stages of disease
Raghavi Sudharsan and William Beltran by a microscope in a lab.

Raghavi Sudharsan and William Beltran of the Division of Experimental Retinal Therapies at Penn’s School of Veterinary Medicine.

nocred

New tools to treat retinal degenerations at advanced stages of disease

A collaborative team of researchers led by vision scientists at the School of Veterinary Medicine have developed novel promoters that drive strong and specific gene expression in rod and cone photoreceptors in mid-to-late stages of disease, potentially offering new and improved options for gene therapy.

3 min. read

Promising inhibitor combination for hard-to-treat leukemia subtypes
Andres Blanco in a lab at Penn Vet.

Andrés Blanco is an assistant professor of biomedical science at Penn’s School of Veterinary Medicine.

(Image: John Donges)

Promising inhibitor combination for hard-to-treat leukemia subtypes

Researchers from Penn Vet and other institutions have identified a novel inhibitor combination of molecules that induce terminal differentiation for the treatment of human non-APL subtypes of AML.

From Penn Vet

2 min. read

Penn breaks ground on Gail P. Riepe Center for Advanced Veterinary Education
Eight people on stage with shovels for ceremonial groundbreaking.

The University of Pennsylvania and School of Veterinary Medicine community celebrated the groundbreaking of the Gail P. Riepe Center for Advanced Veterinary Education. (Left to right:) Scarlett Loya, Amy Durham, J. Larry Jameson, Jim Riepe, Gail Riepe, Andrew M. Hoffman, Robert Marookian, and Barbara Dallap Schaer.

(Image: Lisa Godfrey)

Penn breaks ground on Gail P. Riepe Center for Advanced Veterinary Education

A gift from Penn alumni Gail and Jim Riepe will support the construction of the 11,800-square-foot facility at Penn Vet’s New Bolton Center campus.

3 min. read

Armoring CAR T cells to take on cancer
3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read