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New technology is poised to bring gene therapy to common chronic diseases

New technology is poised to bring gene therapy to common chronic diseases

New research from Penn Medicine reveals a safe delivery system of DNA-loaded lipid nanoparticles directly to cells, which could transform treatment for common chronic diseases like heart disease, diabetes, and cancer.

From Penn Medicine News

2 min. read

Brain power on display at the Franklin Institute
Oblong-shaped terminals and wall art portraying the workings of the brain.

Image: Courtesy of the Franklin Institute

Brain power on display at the Franklin Institute

Several researchers from Penn Medicine’s Department of Neurology are featured throughout the Franklin Institute’s Body Odyssey exhibit.

Kelsey Geesler

1 min. read

Pursuing vaccines to stop celiac disease
A researcher holding a vaccine vial in a lab next to a microscope.

Image: iStock/nuttapong punna

Pursuing vaccines to stop celiac disease

Scientists at Penn’s Institute for RNA Innovation are using messenger RNA to stop the immune response that triggers celiac disease symptoms.

Alex Gardner

Penn Center for Innovation celebrates 10 years
Scientists holding a model of something (forthcoming)

(Image: Eric Sucar)

Penn Center for Innovation celebrates 10 years

The University’s nexus for technology transfer supports researchers in their innovative efforts, from CAR T to mRNA advancements that have dramatically reshaped the world.
Refining lipid nanoparticles for better mRNA therapies
Microscopic rendering of mRNA inside a lipid nanoparticle.

Image: iStock/Love Employee

Refining lipid nanoparticles for better mRNA therapies

A new method developed by Penn engineers for designing ionizable lipids is expected to have broad implications for mRNA-based vaccines and therapeutics.

Ian Scheffler

Novel mRNA vaccine prevents and treat C. difficile
Microscopic view of C. difficile.

Image: iStock/Dr_Microbe

Novel mRNA vaccine prevents and treat C. difficile

Penn Medicine and the Children’s Hospital of Philadelphia have developed the first mRNA vaccine against C. difficile to successfully ward off the bacterial infection.

Alex Gardner

A year after the Nobel Prize, Penn’s mRNA research is revving up
A lab worker with latex gloves doing mRNA research.

The flurry of new innovation in mRNA beyond COVID-19 vaccines began prior to Drew Weissman and Katalin Karikó’s Nobel, but the award has only built on the wave of enthusiasm for mRNA research.

(Image: Dan Burke)

A year after the Nobel Prize, Penn’s mRNA research is revving up

In 2023, Drew Weissman and Katalin Karikó received Nobel Prize recognition for mRNA vaccines. Today, the work continues apace as successes across the University show how medicine is changing rapidly as a result of the prize-winning discovery.

Alex Gardner