A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the body’s bouncer, “deciding” which foreign materials get degraded by immune cells and which are allowed entry.
(Image / iStock Md Saiful Islam Khan)
Decoding ancient immunity networks
A collaborative team from Penn Medicine and Penn Engineering have unraveled the mathematics of a 500-million-year-old protein network that “decides” which foreign materials are friend or foe.
In eusocial superorganisms like leafcutter ant colonies, labor is divvied up according to body shape and size, but PIK Professor Shelley Berger and her team discovered that molecular signals can override that blueprint. Their findings reveal how simple neuropeptides can reprogram ant behavior, reshuffling roles in nature’s most disciplined workforce.
(Image: Courtesy of Tierney Scarpa)
What can ants and naked-mole rats teach about societal roles?
PIK Professor Shelley Berger and colleagues explored the genetic basis of labor distribution in communal-dwelling species and discovered that pathways dating back hundreds of millions of years are conserved across animal kingdoms. Their findings offer fundamental insights into complex social behaviors.
Penn’s AI x Science Postdoctoral Fellows Program is breaking down traditional scientific boundaries by integrating artificial intelligence across diverse research fields. Less than a year in, the program is already paying dividends in the form of new collaborations and research publications for inaugural fellows like Brynn Sherman (left) of the School of Arts & Sciences and Kieran Murphy (right) of the School of Engineering and Applied Science.
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AI x Science Postdoctoral Fellows collaborate across disciplines
The new fellowship program, offered through the School of Arts & Sciences and the School of Engineering and Applied Science, offers mentorship and peer engagement opportunities.
An interdisciplinary team led by School of Engineering and Applied Science’s Lee C. Bassett and Dani Bassett, also of the School of Arts & Sciences, have studied the mechanical properties of prions, the mysterious shape-shifting proteins that are infamous for mad cow disease yet essential for yeast survival
Researchers led by César de la Fuente of the Perelman School of Medicine have created new peptides that fight hard-to-treat “superbug” infections by punching holes in bacterial cells and stimulating immune cells to signal for more defenders.
(Image: Courtesy of Jianing Bai)
Delivering a one-two punch to superbugs to fight infections
Penn researchers create mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.
Image: Courtesy of NASA’s Jesse Allen, Earth Observatory
Paris Perdikaris led research on lifesaving and more cost-effective weather predictions
Penn professor Paris Perdikaris and collaborators developed Aurora, a machine-learning model that has predictive capabilities for air quality, ocean waves, tropical cyclone tracks, and weather.
Lillian Miller (left) graduated as a chemistry and environmental scieces double major in May. This summer, she returns to begin her graduate training in Irina Marinov’s (right), where researchers use big data and computational techniques to make better climate models.
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Lillian Miller: May grad turned Penn Ph.D.
Lillian Miller, a May graduate from the College, will begin graduate studies in the laboratory of Irina Marinov this summer, where she is leveraging big data to tackle ocean and climate-focused research.
Bhuvnesh Jain of the School of Arts & Sciences has teamed up with PIK University Professor René Vidal of the Perelman School of Medicine and the School of Engineering and Applied Science to create the AI x Science Fellowship offering postdoctoral researchers across the University opportunities to collaborate across disciplines.
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AI x Science Postdoctoral Fellowship
Bhuvnesh Jain and René Vidal have teamed up to create the AI x Science Fellowship, which builds on the thriving postdoctoral program of the Data Driven Discovery Initiative to foster cross-disciplinary collaboration among researchers across the University.
The soul of an artist, the mind of a mathematician
An artist, author, engineer, mathematician, and mentor, PIK Professor in the School of Arts & Sciences and the School of Engineering and Applied Science Robert Ghrist embraces innovation to enrich each of these roles.
Four faculty have been elected to the National Academy of Sciences in recognition of their innovative contributions to original scientific research. The newly honored scholars are Mark Devlin (top left) from the School of Arts & Sciences and Katalin Karikó (top right), Virginia M.Y. Lee (bottom left), and E. John Wherry III (bottom right) from the Perelman School of Medicine.
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National Academy of Sciences elects four from Penn
The newly elected members, recognized for their innovative contributions to original research, are Mark Devlin of the School of Arts & Sciences and Katalin Karikó, Virginia Lee, and E. John Wherry III of the Perelman School of Medicine.
