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Decoding ancient immunity networks
Hand holding a blood vial that reads "complement (C3 + C4)"

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the body’s bouncer, “deciding” which foreign materials get degraded by immune cells and which are allowed entry.

(Image / iStock Md Saiful Islam Khan)

Decoding ancient immunity networks

A collaborative team from Penn Medicine and Penn Engineering have  unraveled the mathematics of a 500-million-year-old protein network that “decides” which foreign materials are friend or foe.

Nathi Magubane , Ian Scheffler , Holly Wojcik , Matt Toal

5 min. read

What is an NPU? A Penn expert explains
A computer chip being placed by a rubber-gloved hand.

Image: Narumon Bowonkitwanchai via Getty Images

  • Q&A

    • What is an NPU? A Penn expert explains

    Benjamin C. Lee, a professor of electrical and systems engineering, explains what a neural processing unit (NPU) is and why it matters in the age of artificial intelligence.

    5 min. read

    How cable news has diverged from broadcast news
    Person sitting on couch watching news.

    Image: simonkr via Getty Images

    How cable news has diverged from broadcast news

    A team of researchers from the Computational Social Science Lab at the University of Pennsylvania find that cable news has increasingly diverged from broadcast news in the topics covered and language used.

    3 min. read

    AI x Science Postdoctoral Fellows collaborate across disciplines
    Sibe-by-side portraits of Brynn Sherman, on left, and Kieran Murphy, right.

    Penn’s AI x Science Postdoctoral Fellows Program is breaking down traditional scientific boundaries by integrating artificial intelligence across diverse research fields. Less than a year in, the program is already paying dividends in the form of new collaborations and research publications for inaugural fellows like Brynn Sherman (left) of the School of Arts & Sciences and Kieran Murphy (right) of the School of Engineering and Applied Science.

    nocred

    AI x Science Postdoctoral Fellows collaborate across disciplines

    The new fellowship program, offered through the School of Arts & Sciences and the School of Engineering and Applied Science, offers mentorship and peer engagement opportunities.

    5 min. read

    New class of materials passively harvest water from air
    A water droplet reflecting the color spectrum.

    Image: MamiGibbs via Getty Images

    New class of materials passively harvest water from air

    Researchers at Penn Engineering have discovered a new class of nanostructured materials that can pull water from the air, which could enable new ways to collect water in arid regions and devices that cool electronics or buildings using the power of evaporation.

    Melissa Pappas

    2 min. read

    Unlocking the mechanics of protein misfolding
    Artist's interpretation of prion mechanics.

    Mathieu Ouellet

    Unlocking the mechanics of protein misfolding

    An interdisciplinary team led by School of Engineering and Applied Science’s Lee C. Bassett and Dani Bassett, also of the School of Arts & Sciences, have studied the mechanical properties of prions, the mysterious shape-shifting proteins that are infamous for mad cow disease yet essential for yeast survival

    5 min. read

    Delivering a one-two punch to superbugs to fight infections
    Rakesh Krishnan sits at a computer staring at a 3D rendering of a protein.

    Researchers led by César de la Fuente of the Perelman School of Medicine have created new peptides that fight hard-to-treat “superbug” infections by punching holes in bacterial cells and stimulating immune cells to signal for more defenders.

    (Image: Courtesy of Jianing Bai) 

    Delivering a one-two punch to superbugs to fight infections

    Penn researchers create mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.

    3 min. read

    Penn students innovate in the time of AI
    Helen Jin, Davis Brown

    Helen Jin and Davis Brown.

    nocred

    Penn students innovate in the time of AI

    Students from schools across the University are putting knowledge into practice, asking deep questions and finding innovative uses for AI tools.

    5 min. read

    AI x Science Postdoctoral Fellowship
    Aerial shot of Amy Guttman Hall

    Bhuvnesh Jain of the School of Arts & Sciences has teamed up with PIK University Professor René Vidal of the Perelman School of Medicine and the School of Engineering and Applied Science to create the AI x Science Fellowship offering postdoctoral researchers across the University opportunities to collaborate across disciplines.

    nocred

    AI x Science Postdoctoral Fellowship

    Bhuvnesh Jain and René Vidal have teamed up to create the AI x Science Fellowship, which builds on the thriving postdoctoral program of the Data Driven Discovery Initiative to foster cross-disciplinary collaboration among researchers across the University.

    6 min. read