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Stress tested, testing stress: Novel organoid models how the adrenal gland develops
Michinori Mayama (left) is showing a culture dish to Kotaro Sasaki (right) in a lab.

Michinori Mayama (left) and Kotaro Sasaki (right). 

(Image: Courtesy of Kotaro Sasaki)

Stress tested, testing stress: Novel organoid models how the adrenal gland develops

Researchers led by Penn Vet’s Kotaro Sasaki and Michinori Mayama have developed an organoid system that faithfully mimics how the human adrenal gland develops and forms complex tissue structures, providing a powerful tool to study adrenal biology and laying the groundwork for regenerative therapies targeting adrenal diseases.
Mikhaidia Miller: First-gen perspectives on nursing, health equity, and what’s next
Mikhaidia Miller wearing a striped sweater and standing with arms crossed, smiling and facing sideways, in the Penn First Plus office.

A first-generation student graduating from the School of Nursing, fourth-year Mikhaidia Miller has benefited from Penn First Plus mentorship, programming, and resources throughout her time at Penn. She aims to become a certified registered nurse anesthetist and help improve health equity for all patients.

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Mikhaidia Miller: First-gen perspectives on nursing, health equity, and what’s next

The fourth-year reflects on what underpins her desire to pursue a nursing career and how Penn First Plus has supported her as a first-generation student.

3 min. read

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Pancreatic cancer cells.

Image: Nemes Laszlo/Science Photo Library via Getty Images

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer

Research led by Penn Vet’s Ellen Puré has used lipid nanoparticles to generate CAR T cells directed at a type of tumor support cells—cancer-associated fibroblasts—melting away the protective barrier around pancreatic tumor cells and paving the way for a potentially safer, more accessible, and cost-effective method to treat solid tumors.
The big reveal: Penn Medicine’s Match Day 2026
Two Penn Med students and two others under a 2026 balloon at Penn’s 2026 Match Day.

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The big reveal: Penn Medicine’s Match Day 2026

The Perelman School of Medicine’s graduating class of 2026 celebrated Match Day on March 20, revealing the location of their residencies with a celebration among faculty, friends, and family.

1 min. read

A stiff defense: Rethinking gum disease
A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

(Image: Hardik Makkar)

A stiff defense: Rethinking gum disease

Penn Dental Medicine’s Kyle H. Vining and Hardik Makkar take a biomaterials approach to understanding periodontal disease, using a hydrogel system to investigate how the physical properties of the gum tissue impact inflammation.

3 min. read

A topical cream may prevent or slow growth of some common skin cancers

A topical cream may prevent or slow growth of some common skin cancers

An experimental cream developed at Penn Medicine that blocks a specific enzyme may offer a precise, better‑tolerated path to prevent and treat cutaneous squamous cell carcinoma.

Alex Gardner

1 min. read

Penn experts propose a tobacco playbook for food policy
A tablet with biometric stats on a desk with fresh produce and legumes.

Image: ruizluquepaz via Getty Images

Penn experts propose a tobacco playbook for food policy

Drawing on public policies that have been successful with tobacco control, Penn’s Center for Food and Nutrition Policy outlines a stronger framework for regulating ultra-processed foods.

Eric Horvath

2 min. read

Human moral agency irreplaceable in the era of artificial intelligence

Human moral agency irreplaceable in the era of artificial intelligence

As artificial intelligence rapidly integrates into clinical settings, an article published in the Hastings Center Report by Penn Nursing’s Connie M. Ulrich warns that the core of nursing, its moral agency, must remain a human-driven responsibility.