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Stress tested, testing stress: Novel organoid models how the adrenal gland develops
Michinori Mayama (left) is showing a culture dish to Kotaro Sasaki (right) in a lab.

Michinori Mayama (left) and Kotaro Sasaki (right). 

(Image: Courtesy of Kotaro Sasaki)

Stress tested, testing stress: Novel organoid models how the adrenal gland develops

Researchers led by Penn Vet’s Kotaro Sasaki and Michinori Mayama have developed an organoid system that faithfully mimics how the human adrenal gland develops and forms complex tissue structures, providing a powerful tool to study adrenal biology and laying the groundwork for regenerative therapies targeting adrenal diseases.

3 min. read

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer
Pancreatic cancer cells.

Image: Nemes Laszlo/Science Photo Library via Getty Images

Targeting tumor supporting cells: Advancing CAR T success in pancreatic cancer

Research led by Penn Vet’s Ellen Puré has used lipid nanoparticles to generate CAR T cells directed at a type of tumor support cells—cancer-associated fibroblasts—melting away the protective barrier around pancreatic tumor cells and paving the way for a potentially safer, more accessible, and cost-effective method to treat solid tumors.

3 min. read

Awards and accolades for six members of Penn faculty
College Hall in spring with Fisher Fine Arts Library.

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Awards and accolades for six members of Penn faculty

A roundup of the latest awards for faculty members at the Wharton School, Penn Vet, Annenberg, Arts & Sciences, and Nursing.

Penn Today Staff

2 min. read

David Holt is making cancer visible
David Holt

David Holt is a small animal professor of surgery at Penn Vet.

(Image: Courtesy of Penn Vet)

David Holt is making cancer visible

Penn Vet’s David Holt advances cancer care with a simple question asked in the operating room: “Have we removed it all?”

Martin Hackett

2 min. read

Chapters of Change: The blossom of Penn’s professional schools in the 19th century
Penn’s campus in 1891.

A view of campus on May 20, 1891, looking northeast toward the corner of 34th and Walnut streets.

(Image: Courtesy of University Archives)

Chapters of Change: The blossom of Penn’s professional schools in the 19th century

“Chapters of Change” highlights key moments of change in Penn’s history, adapting to shifts in society. In the 19th century, the University faced industrialization and more by creating some of its first professional schools.

6 min. read