Deconstructing the mechanics of bone marrow disease Acollaborative team developed an alginate-based hydrogel system that mimics the viscoelasticity of the natural extracellular matrix in bone marrow. By tweaking the balance between elastic and viscous properties in these artificial ECMs, they could recapitulate the viscoelasticity of healthy and scarred fibrotic bone marrow, and study the effects on human monocytes placed into these artificial ECMs. (Image: Adam Graham/Harvard CNS/Wyss Institute at Harvard University) Deconstructing the mechanics of bone marrow disease A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.
Some cancer patients forgo lifesaving medications because of high cost Penn In the News Today.com Some cancer patients forgo lifesaving medications because of high cost PIK Professor Ezekiel Emanuel comments on the problem with the Food and Drug Administration’s accelerated approval program for new cancer drugs. ‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer Penn In the News USA Today ‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer Robert Vonderheide of the Perelman School of Medicine’s Abramson Cancer Center says a big breakthrough in cancer treatment will come soon. One protein’s role in genomic intermingling and T cell development nocred One protein’s role in genomic intermingling and T cell development The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions. Stress protein in fibroblasts may be a good target for future cancer drugs Stress protein in fibroblasts may be a good target for future cancer drugs A Penn study finds the ATF4 protein is overactive in many types of tumor cells and tumor-supporting fibroblasts to promote tumor survival, and may be a good target for future cancer treatments. Blood tests that detect cancers create risks for those who use them Penn In the News The New York Times Blood tests that detect cancers create risks for those who use them Susan Domchek of the Perelman School of Medicine warns that when large numbers of people get tested for cancer false positives become a real problem. Promising results for chemo immunotherapy combination against pancreatic cancer Promising results for chemo immunotherapy combination against pancreatic cancer Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes. Breast cancer drug trial results in ‘unheard-of’ survival rates Penn In the News The New York Times Breast cancer drug trial results in ‘unheard-of’ survival rates Susan Domchek of the Perelman School of Medicine is quoted on a successful breast cancer treatment. Experimental approach to treating pancreatic cancer heralded as a success Penn In the News Today.com Experimental approach to treating pancreatic cancer heralded as a success The Perelman School of Medicine’s Carl June is quoted about a new gene therapy shrank the tumors of a woman with pancreatic cancer. Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer. Load More
‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer Penn In the News USA Today ‘Watershed moment’: Doctors finding new hope in treatments for deadly pancreatic cancer Robert Vonderheide of the Perelman School of Medicine’s Abramson Cancer Center says a big breakthrough in cancer treatment will come soon. One protein’s role in genomic intermingling and T cell development nocred One protein’s role in genomic intermingling and T cell development The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions. Stress protein in fibroblasts may be a good target for future cancer drugs Stress protein in fibroblasts may be a good target for future cancer drugs A Penn study finds the ATF4 protein is overactive in many types of tumor cells and tumor-supporting fibroblasts to promote tumor survival, and may be a good target for future cancer treatments. Blood tests that detect cancers create risks for those who use them Penn In the News The New York Times Blood tests that detect cancers create risks for those who use them Susan Domchek of the Perelman School of Medicine warns that when large numbers of people get tested for cancer false positives become a real problem. Promising results for chemo immunotherapy combination against pancreatic cancer Promising results for chemo immunotherapy combination against pancreatic cancer Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes. Breast cancer drug trial results in ‘unheard-of’ survival rates Penn In the News The New York Times Breast cancer drug trial results in ‘unheard-of’ survival rates Susan Domchek of the Perelman School of Medicine is quoted on a successful breast cancer treatment. Experimental approach to treating pancreatic cancer heralded as a success Penn In the News Today.com Experimental approach to treating pancreatic cancer heralded as a success The Perelman School of Medicine’s Carl June is quoted about a new gene therapy shrank the tumors of a woman with pancreatic cancer. Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer. Load More
One protein’s role in genomic intermingling and T cell development nocred One protein’s role in genomic intermingling and T cell development The findings, from a team led by Golnaz Vahedi of Penn Medicine, could have implications for T-cell based immunotherapies for cancer and other conditions.
Stress protein in fibroblasts may be a good target for future cancer drugs Stress protein in fibroblasts may be a good target for future cancer drugs A Penn study finds the ATF4 protein is overactive in many types of tumor cells and tumor-supporting fibroblasts to promote tumor survival, and may be a good target for future cancer treatments.
Blood tests that detect cancers create risks for those who use them Penn In the News The New York Times Blood tests that detect cancers create risks for those who use them Susan Domchek of the Perelman School of Medicine warns that when large numbers of people get tested for cancer false positives become a real problem. Promising results for chemo immunotherapy combination against pancreatic cancer Promising results for chemo immunotherapy combination against pancreatic cancer Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes. Breast cancer drug trial results in ‘unheard-of’ survival rates Penn In the News The New York Times Breast cancer drug trial results in ‘unheard-of’ survival rates Susan Domchek of the Perelman School of Medicine is quoted on a successful breast cancer treatment. Experimental approach to treating pancreatic cancer heralded as a success Penn In the News Today.com Experimental approach to treating pancreatic cancer heralded as a success The Perelman School of Medicine’s Carl June is quoted about a new gene therapy shrank the tumors of a woman with pancreatic cancer. Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer. Load More
Promising results for chemo immunotherapy combination against pancreatic cancer Promising results for chemo immunotherapy combination against pancreatic cancer Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes.
Breast cancer drug trial results in ‘unheard-of’ survival rates Penn In the News The New York Times Breast cancer drug trial results in ‘unheard-of’ survival rates Susan Domchek of the Perelman School of Medicine is quoted on a successful breast cancer treatment. Experimental approach to treating pancreatic cancer heralded as a success Penn In the News Today.com Experimental approach to treating pancreatic cancer heralded as a success The Perelman School of Medicine’s Carl June is quoted about a new gene therapy shrank the tumors of a woman with pancreatic cancer. Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer. Load More
Experimental approach to treating pancreatic cancer heralded as a success Penn In the News Today.com Experimental approach to treating pancreatic cancer heralded as a success The Perelman School of Medicine’s Carl June is quoted about a new gene therapy shrank the tumors of a woman with pancreatic cancer. Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer. Load More
Reprogrammed cells attack and tame deadly cancer in one woman Penn In the News The New York Times Reprogrammed cells attack and tame deadly cancer in one woman Robert Vonderheide of the Perelman School of Medicine comments on taming pancreatic cancer.