Through
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Cancer Research
A newly identified immune checkpoint protein may lead to future cancer therapies
A newly identified immune checkpoint protein may lead to future cancer therapies
Penn Medicine researchers have found that knocking out a T cell’s CD5 gene greatly enhances the cell’s anticancer activity in a variety of preclinical cancer models.
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
The power of protons
The power of protons
Penn Medicine has treated more than 10,000 cancer patients at three proton therapy centers across the region, including the largest and busiest center in the world—while also leading the way in research to expand the healing potential of these positive particles.
Slowing inflammation may boost immunotherapy’s effectiveness against advanced lung cancer
Slowing inflammation may boost immunotherapy’s effectiveness against advanced lung cancer
Patients with stage 4 lung cancer show high response rates after an anti-inflammatory drug is added temporarily to immune checkpoint inhibitor therapy.
Kotaro Sasaki and his team unveil the genetics of testicular cancer
Kotaro Sasaki and his team unveil the genetics of testicular cancer
Researchers from Penn Vet develop the first in vitro seminoma model, shedding light on chromosomal anomalies and signaling pathways.
New ‘armored’ CAR therapy produces significant responses in cancer patients
New ‘armored’ CAR therapy produces significant responses in cancer patients
For patients whose cancers don't respond to current CAR T cell therapies, a new, modified CAR T cell therapy by Penn’s Carl June shows promise in a phase 1 clinical trial.
Could the liver hold the key to better cancer treatments?
Could the liver hold the key to better cancer treatments?
Penn Medicine researchers have uncovered a liver-based signaling pathway that protects tumors by restraining anticancer immune cells.
Honoring a life scientist’s lifesaving science
Honoring a life scientist’s lifesaving science
Carl June accepted the 2024 Breakthrough Prize in Life Sciences at a Los Angeles ceremony, making him the sixth recipient from Penn.
Study reveals inequities in access to transformative CAR T cell therapy
Study reveals inequities in access to transformative CAR T cell therapy
Penn Medicine researchers have assessed the percentage of patients from minority health populations and reveal inequities in access to transformative CAR T cell therapy.
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Accelerating CAR T cell therapy: Lipid nanoparticles speed up manufacturing
Penn Engineers have developed a novel method for manufacturing CAR T cells using lipid nanoparticles as delivery vehicles.
In the News
Today
How did Shannen Doherty die? What to know about ‘90210’ star’s cause of death
According to Penn Medicine, there is no known cure for metastatic breast cancer.
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Stat
New immunotherapy combination could ‘change the landscape’ of cancer treatment
A study by Andy Minn and postdoc Divij Mathew of the Perelman School of Medicine and colleagues found that a combination checkpoint inhibitor therapy benefited patients with lung cancer.
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Philadelphia Inquirer
Breast cancer strikes young Black women at alarming rate
Oluwadamilola “Lola” Fayanju of the Perelman School of Medicine analyzes the factors causing breast cancer to affect younger women.
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CNN
There’s still no standard test to detect pancreatic cancer early. Scientists are working to change that
A 2020 study from the Perelman School of Medicine found that a blood test to screen for certain biomarkers associated with pancreatic cancer was 92% accurate in its ability to detect disease.
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Associated Press
A new strategy to attack aggressive brain cancer shrank tumors in two early tests
A clinical trial led by Stephen Bagley of the Perelman School of Medicine suggests that targeting two associated proteins with CAR T cell therapy could be a viable strategy for shrinking brain tumors.
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Philadelphia Inquirer
Penn’s BRCA cancer vaccine trial aims to prevent the disease in healthy people
A trial led by Susan Domchek of the Perelman School of Medicine could use a preventive vaccine to protect people with a BRCA gene mutation from cancer.
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