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Immune activation may determine success of dual-target CAR T therapy in glioblastoma

New research from Penn Medicine finds that activation of natural killer cells is linked to longer survival, and suppressive immune cells is tied to poor response.

Chunxiao Sun holding a fungal sample on a petri dish.

Unearthing new cancer treatments from fungi

Penn Engineers led by Xue “Sherry” Gao have developed a gene-editing tool built specifically for fungi, unlocking a hidden library of molecules—including some with early anti-cancer promise—from one of biology’s most overlooked kingdoms.

3 min. read

US Healthcare founder and philanthropist Leonard Abramson dies at 94

Leonard Abramson donated $100 million to the University of Pennsylvania in 1997 to establish the Abramson Family Cancer Research Institute. The gift at the time was the largest ever to a university cancer center.

AI framework aids target discovery for CAR T cell therapy

Researchers at Penn Medicine have created a generalizable strategy to identify new targets for CAR T cell therapy.

2 min. read

CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients

A long-term follow-up from one of the earliest CAR T cell therapy clinical trials shows potential cures in more than one-third of patients treated at Penn Medicine.

2 min. read

Weight-loss drugs may be offer an unexpected clue about breast cancer risk

Elizabeth McDonald of the Perelman School of Medicine and colleagues found that women taking GLP-1 drugs were turning up with breast cancer far less often than expected.

Support for trainees ensures a bright future for BRCA science

The Basser Center for BRCA Postdoctoral Fellowship Program, founded by Ilana Katz Sand and Michael Sand, provides support for one postdoctoral fellow for three years or the last two years of training for a clinical fellow.

University of Pennsylvania study finds a surprising link between Ozempic and breast cancer risk

“This is very exciting because breast cancer is one of the obesity-associated cancers, and bariatric surgery, while effective to reduce breast cancer risk, is not scalable at a population level,” says Elizabeth McDonald of the Perelman School of Medicine.

New CAR T treatment opens doors for kidney patients

An early Penn Medicine trial demonstrates CAR T cells can safely desensitize even the most challenging transplant candidates.

2 min. read

GLP-1 use linked to lower breast cancer incidence in large cohort study

A retrospective analysis of more than 110,000 women between the ages of 45 and 80 found that those who take GLP-1 medications are about 30% less likely to develop breast cancer than those who do not take GLP-1 medications.

2 min. read

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Immune activation may determine success of dual-target CAR T therapy in glioblastoma

Unearthing new cancer treatments from fungi

US Healthcare founder and philanthropist Leonard Abramson dies at 94

AI framework aids target discovery for CAR T cell therapy

CAR T cell therapy leads to 10-year remissions in B-cell lymphoma patients

Weight-loss drugs may be offer an unexpected clue about breast cancer risk

Support for trainees ensures a bright future for BRCA science

University of Pennsylvania study finds a surprising link between Ozempic and breast cancer risk

New CAR T treatment opens doors for kidney patients

GLP-1 use linked to lower breast cancer incidence in large cohort study