The compassionate team behind CAR T cancer breakthroughs (From left) Research coordinator Nicolas Sarmiento, project manager Reenie Martins, research coordinator Lee Dengel, and trial sample coordinator Rutendo Manyeka document and prepare paperwork required for T-cell infusion.(Image: Courtesy of Penn Medicine News) The compassionate team behind CAR T cancer breakthroughs The clinical trial support staff at Penn Medicine and the Abramson Cancer Center have helped execute the team science that brings research discoveries from the lab bench to the bedside.
New ways to modulate cell activity remotely Cells are dynamic, fast-changing, complex, tiny, and often hard-to-see in environments that don’t always behave in predictable ways when exposed to external stimuli. Now, researchers led by Lukasz Bugaj of the School of Engineering and Applied Science have found new ways to modulate cell activity remotely.(Image: iStock/Maksim Tkachenko) New ways to modulate cell activity remotely Penn researchers use temperature to guide cellular behavior, promising better diagnostics and targeted therapies.
Scientists create tiny anticancer weapons that make tumors destroy themselves Penn In the News Interesting Engineering Scientists create tiny anticancer weapons that make tumors destroy themselves Xiaowei (George) Xu of the Perelman School of Medicine and colleagues have unveiled an innovative approach to cancer treatment that leverages tiny capsules known as small extracellular vesicles to target a specific receptor on tumor cells. Developing a tiny anticancer weapon Image: iStock/Bahaa_Aladdin Developing a tiny anticancer weapon Penn Medicine researchers have developed tumor-homing nanosized particles that trigger cancer cell self-destruction in preclinical tests. Discovery links cellular structures to kidney cancer treatment outcomes Image: iStock/Mohammed Haneefa Nizamudeen Discovery links cellular structures to kidney cancer treatment outcomes New research from Penn Medicine finds patterns in cells of tumors may guide personalized therapies for clear cell renal cell carcinoma. New tool puts reproductive risk for BRCA carriers into perspective Image: iStock/baona New tool puts reproductive risk for BRCA carriers into perspective A team at Penn Medicine has created a resource to help inform reproductive counseling for cancer gene mutation carriers. Generic platinum chemotherapy shortages did not increase deaths Image: iStock/SeventyFour Generic platinum chemotherapy shortages did not increase deaths A national data analysis finds that short-term mortality was not impacted by the shortage for patients with advanced cancers. Brain tumor organoids accurately model patient response to CAR T cell therapy A patient-derived glioblastoma organoid treated with dual-target CAR-T cells. T cells (magenta) infiltrate the tumor organoid and kill tumor cells (blue; yellow indicates dying cells).(Image: Yusha Sun and Xin Wang from the laboratories of Guo-li Ming and Hongjun Song) Brain tumor organoids accurately model patient response to CAR T cell therapy Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine. 2 min. read Keto diet metabolite may power up CAR T cells to kill cancer Image: iStock/Naeblys Keto diet metabolite may power up CAR T cells to kill cancer Laboratory studies reveal a potentially low-tech intervention to improve personalized cell therapy. Keto diet supplement could boost a cancer treatment's effectiveness Penn In the News HealthDay Keto diet supplement could boost a cancer treatment's effectiveness A study by Perelman School of Medicine student Puneeth Guruprasad and postdoc Shan Liu suggests that a component of the keto diet could boost CAR T cell therapy to help treat cancer. Load More
Developing a tiny anticancer weapon Image: iStock/Bahaa_Aladdin Developing a tiny anticancer weapon Penn Medicine researchers have developed tumor-homing nanosized particles that trigger cancer cell self-destruction in preclinical tests.
Discovery links cellular structures to kidney cancer treatment outcomes Image: iStock/Mohammed Haneefa Nizamudeen Discovery links cellular structures to kidney cancer treatment outcomes New research from Penn Medicine finds patterns in cells of tumors may guide personalized therapies for clear cell renal cell carcinoma.
New tool puts reproductive risk for BRCA carriers into perspective Image: iStock/baona New tool puts reproductive risk for BRCA carriers into perspective A team at Penn Medicine has created a resource to help inform reproductive counseling for cancer gene mutation carriers.
Generic platinum chemotherapy shortages did not increase deaths Image: iStock/SeventyFour Generic platinum chemotherapy shortages did not increase deaths A national data analysis finds that short-term mortality was not impacted by the shortage for patients with advanced cancers.
Brain tumor organoids accurately model patient response to CAR T cell therapy A patient-derived glioblastoma organoid treated with dual-target CAR-T cells. T cells (magenta) infiltrate the tumor organoid and kill tumor cells (blue; yellow indicates dying cells).(Image: Yusha Sun and Xin Wang from the laboratories of Guo-li Ming and Hongjun Song) Brain tumor organoids accurately model patient response to CAR T cell therapy Lab-grown tumors respond to cell therapy the same as tumors in the patients’ brains, according to researchers at Penn Medicine. 2 min. read
Keto diet metabolite may power up CAR T cells to kill cancer Image: iStock/Naeblys Keto diet metabolite may power up CAR T cells to kill cancer Laboratory studies reveal a potentially low-tech intervention to improve personalized cell therapy.
Keto diet supplement could boost a cancer treatment's effectiveness Penn In the News HealthDay Keto diet supplement could boost a cancer treatment's effectiveness A study by Perelman School of Medicine student Puneeth Guruprasad and postdoc Shan Liu suggests that a component of the keto diet could boost CAR T cell therapy to help treat cancer.