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Veterinary Medicine

Rewiring blood cells to give rise to precursors of sperm
microscopic image with blue, red, and green fluorescent labeling indicates cells that are developing to resemble germ cells

Providing the inducible pluripotent stem cells with appropriate growth conditions and signals, the research team was able to coax the cells to begin to resemble primordial germ cells found in marmoset embryos.

(Image: Yasunari Seita)

Rewiring blood cells to give rise to precursors of sperm

School of Veterinary Medicine researchers teamed with scientists at the University of Texas at San Antonio to transform blood cells to regain a flexible fate, growing into a precursor of sperm cells.

Katherine Unger Baillie

Trained dogs can sniff out a deadly deer disease
A Finnish spitz dog sniffs at a jar labeled CWD+

Jari, an 8-year-old Finnish spitz, takes in the odor of a sample taken from a deer with chronic wasting disease. Penn Vet scientists are working to see whether detection dogs trained to discern the disease’s scent could be employed as a tool in helping contain its spread.

(Image: Shelby Wise/Wise K9 Photography)

Trained dogs can sniff out a deadly deer disease

The proof-of-concept investigation by School of Veterinary Medicine researchers suggests detection dogs could be an asset in the effort to identify, contain, and manage chronic wasting disease, a highly contagious ailment.

Katherine Unger Baillie

Harnessing an innate protection against Ebola
fluorescent microscopic image of two cells being infected with virus

An innate mechanism in human cells may prevent Ebola virus from spreading, according to new Penn Vet-led research. Using powerful confocal microscopy, they tracked the budding of virus-like particles from cells (shown in the filamentous projections in the cell in the upper right) and how autophagy, a “self-eating” cellular process, by which viral proteins are sequestered in vesicles (shown in the cell in the lower left), inhibits virus-like particles from exiting.

(Image: Courtesy of the Harty lab)

Harnessing an innate protection against Ebola

School of Veterinary Medicine researchers have identified a cellular pathway that keeps Ebola virus from exiting human cells, with implications for developing new antivirals.

Katherine Unger Baillie