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How tumor mechanics and tiny messengers could shape the future of cancer research

How tumor mechanics and tiny messengers could shape the future of cancer research

A literature review co-written by Penn Engineering Ph.D. student Kshitiz Parihar and Ravi Radhakrishnan, professor in bioengineering and chemical biomolecular engineering, highlights the hidden connections between tumor mechanics and extracellular vesicles (EVs), tiny packages of proteins and genetic material secreted by cells. EVs carry cargo like proteins and RNA between cells, influencing how tumors grow, how the immune system responds, and even how cancers spread to other parts of the body.

What stiffening lung tissue reveals about the earliest stages of fibrosis
Donia Ahmed prepares tissue for imaging.

Image: Courtesy of Penn Engineering Today

What stiffening lung tissue reveals about the earliest stages of fibrosis

A Penn Engineering team has targeted the lung’s extracellular matrix to better understand early fibrosis by triggering the formation of special chemical bonds that increase tissue stiffness in specific locations, mimicking the first physical changes that may lead to lung fibrosis.

Melissa Pappas

2 min. read

A generative AI model that designs new antibiotics
Pranam Chatterjee in his lab at Penn Engineering.

The lab of Pranam Chatterjee (pictured), in collaboration with the lab of César de la Fuente, developed and validated a new “diffusion model” that can generate antibiotic candidates the same way AI creates images.

(Image: Sylvia Zhang)

A generative AI model that designs new antibiotics

A research team at Penn Engineering has developed and validated a new ‘diffusion model’ that can generate antibiotic candidates the same way AI creates images.

Ian Scheffler

2 min. read

AI uncovers new antibiotics in ancient microbes
Cesar de la Fuente in his lab.

César de la Fuente (pictured) and his team used AI to study the proteins of hundreds of ancient microbes, searching for new antibiotic candidates.

(Image: Jianing Bai)

AI uncovers new antibiotics in ancient microbes

César de la Fuente uses AI to hunt for new antibiotic candidates in unlikely places, from the DNA of extinct organisms to the proteins of ancient microbes.

Ian Scheffler

2 min. read

Centuries after discovery, red blood cells still hold surprises
Four microscopic views of red blood cells.

In these microscopic close-ups, samples of red blood cells aggregate from left to right, becoming more compact despite the absence of platelets, long thought essential to clotting.

(Image: Rustem Litvinov)

Centuries after discovery, red blood cells still hold surprises

In a new collaborative study, researchers at Penn turned to mechanical engineering to understand how blood clots can compact, even without platelets.

Ian Scheffler

2 min. read

A nature-inspired leap in water harvesting technology

A nature-inspired leap in water harvesting technology

Penn Engineering’s Shu Yang and postdoctoral fellow Yunchan Lee are working to develop a new material and device that imitate raspberries and sunflowers. Together, these bio-inspired forms make clean, sustainable water harvesting possible by using just the moisture in the air and the heat of the sun.

What ever-growing incisors can teach us about genetic disease
Microscopic view of a mouse incisor.

An image taken through scanning electron microscopy (SEM) shows a polished sagittal section through a mouse mandibular incisor, showing the different mineralized tissue layers.

(Image: Courtesy of Penn Engineering Today)

What ever-growing incisors can teach us about genetic disease

An interdisciplinary team of researchers approaches the question ‘How do teeth mineralize?’ by analyzing the physical, biological, and genetic properties of teeth for real-world clinical applications in the future.

Melissa Pappas

2 min. read

AI finds hundreds of potential antibiotics in snake and spider venom
Venom on the Fang of a Diamondback Rattlesnake

Image: McDonald Wildlife Photography Inc. via Getty Images

AI finds hundreds of potential antibiotics in snake and spider venom

Research from the lab of César de la Fuente on an AI-powered screen of global venom libraries uncovers dozens of promising drug candidates.

Eric Horvath

2 min. read