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Four third-years receive Goldwater Scholarships
(Top row) Shreya Nair and Ian Peng. (Bottom row) Pranav Sompalle and Emily Valerio.

(Top row) Shreya Nair and Ian Peng. (Bottom row) Pranav Sompalle and Emily Valerio.

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Four third-years receive Goldwater Scholarships

Goldwater Scholarships are awarded to students planning research careers in the sciences, engineering, and mathematics.

3 min. read

A stiff defense: Rethinking gum disease
A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

A section of healthy human gum tissue captured using an imaging technique called Second Harmonic Generation microscopy. In this sample, collagen fibers (shown in yellow), which give healthy gums their firm, resilient stiffness, are dense and well-organized—acting as a supportive scaffold for the surrounding cells (shown in teal).

(Image: Hardik Makkar)

A stiff defense: Rethinking gum disease

Penn Dental Medicine’s Kyle H. Vining and Hardik Makkar take a biomaterials approach to understanding periodontal disease, using a hydrogel system to investigate how the physical properties of the gum tissue impact inflammation.

3 min. read

When bone behaves like a sponge
Three members of the Tertuliano lab looking at a computer in the lab.

To visualize the nanoscale structures, the Tertuliano lab often uses large-scale models like the one pictured.

(Image: Sylvia Zhang)

When bone behaves like a sponge

Penn Engineers in the Tertuliano Lab have developed a nanoengineered 3D-printed scaffold for observing how cells feel force.

Melissa Pappas

2 min. read

Penn fourth-year Yash Rajpal named 2026-27 Luce Scholar
Yash Rajpal

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Penn fourth-year Yash Rajpal named 2026-27 Luce Scholar

Yash Rajpal, a University of Pennsylvania fourth-year student in the College of Arts & Sciences and the School of Engineering & Applied Science, is one of 16 recipients selected by the Henry Luce Foundation to be a 2026-27 Luce Scholar.

1 min. read

Engineers sharpen gene-editing tools to target cystic fibrosis
Engineering researchers at a whiteboard in the Gao lab.

Beyond cystic fibrosis, the refined base editor could help researchers tackle a wide range of genetic diseases caused by single-letter DNA changes.

(Image: Bella Ciervo)

Engineers sharpen gene-editing tools to target cystic fibrosis

Researchers at Penn Engineering have developed a modified base-pair editor that offers improved accuracy and could help treat diseases like cystic fibrosis.

Ian Scheffler

2 min. read

Leveraging AI to help stroke survivors recover speech abilities
Shreya Parchure in a white coat in the Laboratory for Cognition and Neural Stimulation in the Goddard Laboratory on Penn's campus, smiling with arms crossed and facing forward.

Shreya Parchure, an M.D.-Ph.D. candidate at Penn, conducts much of her AI-driven research in the Laboratory for Cognition and Neural Stimulation, focusing on ways to personalize speech therapy for patients with post-stroke aphasia.

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Leveraging AI to help stroke survivors recover speech abilities

Doctoral student Shreya Parchure and her team evaluated the usefulness of an AI tool for personalizing speech therapy for patients with post-stroke aphasia.

4 min. read

Physics of foam strangely resembles AI training
Six separate piles of foam.

Image: Dowprasook Deenu via Getty Images

Physics of foam strangely resembles AI training

Research by Penn Engineers reveals that as foams flow ceaselessly inside while holding their external shape, and this internal motion resembles the process of deep learning, the method typically used to train modern AI systems.

Ian Scheffler

2 min. read

Lifesaving breakthrough in bacterial behavior
Artist's rendering of bacteria moving through a nanofabricated tube.

(Pictured) An artist’s depiction of a single cell moving through the nanofabricated mictostrucures biophysicist Arnold Mathijssen’s team used to study E. coli.

(Image: Courtesy of Ruoshui Liu/Cylos Studio)

Lifesaving breakthrough in bacterial behavior

Bacteria can actively swim upstream, leading to severe infections in places like the urinary tract and respiratory system and contamination of medical devices like catheters. Biophysicist Arnold Mathijssen and colleagues have uncovered how and why this happens, revealing that E. coli actually “thrives under pressure.” Their findings point to new strategies for designing safer, more effective biomedical tools and treatments.

3 min. read

Nanoparticle blueprints reveal path to smarter medicines
Hannah Yamagata, Research Assistant Professor Kushol Gupta and postdoctoral fellow Marshall Padilla, holding 3D-printed models of nanoparticles in a lab.

(From left) Doctoral student Hannah Yamagata, research assistant professor Kushol Gupta, and postdoctoral fellow Marshall Padilla holding 3D-printed models of nanoparticles.

(Image: Bella Ciervo)

Nanoparticle blueprints reveal path to smarter medicines

New research involving Penn Engineering shows detailed variation in lipid nanoparticle size, shape, and internal structure, and finds that such factors correlate with how well they deliver therapeutic cargo to a particular destination.

Ian Scheffler

2 min. read