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Bioengineering

Delivering a one-two punch to superbugs to fight infections
Rakesh Krishnan sits at a computer staring at a 3D rendering of a protein.

Researchers led by César de la Fuente of the Perelman School of Medicine have created new peptides that fight hard-to-treat “superbug” infections by punching holes in bacterial cells and stimulating immune cells to signal for more defenders.

(Image: Courtesy of Jianing Bai) 

Delivering a one-two punch to superbugs to fight infections

Penn researchers create mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.

3 min. read

AI x Science Postdoctoral Fellowship
Aerial shot of Amy Guttman Hall

Bhuvnesh Jain of the School of Arts & Sciences has teamed up with PIK University Professor René Vidal of the Perelman School of Medicine and the School of Engineering and Applied Science to create the AI x Science Fellowship offering postdoctoral researchers across the University opportunities to collaborate across disciplines.

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AI x Science Postdoctoral Fellowship

Bhuvnesh Jain and René Vidal have teamed up to create the AI x Science Fellowship, which builds on the thriving postdoctoral program of the Data Driven Discovery Initiative to foster cross-disciplinary collaboration among researchers across the University.

6 min. read

Performer, biomedical engineer, and soon-to-be graduate
Jordyn Harris standing among lights

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Performer, biomedical engineer, and soon-to-be graduate

A performer and dancer, fourth-year Jordyn Harris has been a work-study student for the Platt House and managed tech for myriad student shows, while also advising engineering first-years and working as a researcher at a hospital.

5 min. read

Microrobots navigate diverse oral environments to deliver therapies

Microrobots navigate diverse oral environments to deliver therapies

Penn Engineers and clinicians at the Center for Innovation & Precision Dentistry are developing shapeshifting microrobots capable of navigating the complex environments of the mouth to deliver targeted treatments.

Armoring CAR T cells to take on cancer
 3D visualization showing a reddish-blue tumor mass with internal vasculature, surrounded by blue CAR T cells and small extracellular vesicles against a dark background.

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

Armoring CAR T cells to take on cancer

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have uncovered how solid tumors manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

3 min. read

Scientists unlock frogs’ antibacterial secrets to combat superbugs
A tree frog in Thailand.

The researchers theorized that frogs must have developed antibiotics to survive in their challenging environment.

Image: Michael Edward via Getty Images

Scientists unlock frogs’ antibacterial secrets to combat superbugs

The lab of César de la Fuente has created synthetic peptides, a class of antibiotics, derived from the secretions of a frog commonly found in South Asia.

Ian Scheffler

2 min. read

Meniscus injuries may soon be treated by customizable hydrogel

Meniscus injuries may soon be treated by customizable hydrogel

Researchers at the Perelman School of Medicine found a new 3D-printed customizable hydrogel performed well in preclinical trials with several different types of meniscal tears, offering a potential mend for common joint injuries.

Frank Otto

1 min. read

2025 CAREER Award recipient: Jina Ko

2025 CAREER Award recipient: Jina Ko

Ko, a professor in bioengineering in Penn Engineering and in Pathology and Laboratory Medicine in the Perelman School of Medicine, is awarded the 2025 National Science Foundation (NSF) CAREER Award for her expertise across bioengineering, molecular biology, and chemistry in developing transformative technologies for molecular diagnostics of diseases, especially with respect to how brain-related conditions are diagnosed and treated.