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Bioengineering

Penn engineers turn toxic fungus into anti-cancer drug
Qiuyue Nie and Maria Zotova, from left, purify samples of the fungus in a lab.

First author Qiuyue Nie (left) and coauthor Maria Zotova purify samples of the fungus.

(Image: Bella Ciervo)

Penn engineers turn toxic fungus into anti-cancer drug

Penn-led researchers have isolated a new class of molecules from Aspergillus flavus, a toxic crop fungus, and modified it into a promising cancer-killing compound

Ian Scheffler

2 min. read

Decoding ancient immunity networks
Hand holding a blood vial that reads "complement (C3 + C4)"

A collaborative team from the School of Engineering and Applied Science and the Perelman School of Medicine have unraveled the mathematics of a 500-million-year-old protein network that acts like the body’s bouncer, “deciding” which foreign materials get degraded by immune cells and which are allowed entry.

(Image / iStock Md Saiful Islam Khan)

Decoding ancient immunity networks

A collaborative team from Penn Medicine and Penn Engineering have  unraveled the mathematics of a 500-million-year-old protein network that “decides” which foreign materials are friend or foe.

Nathi Magubane , Ian Scheffler , Holly Wojcik , Matt Toal

5 min. read

Delivering a one-two punch to superbugs to fight infections
Rakesh Krishnan sits at a computer staring at a 3D rendering of a protein.

Researchers led by César de la Fuente of the Perelman School of Medicine have created new peptides that fight hard-to-treat “superbug” infections by punching holes in bacterial cells and stimulating immune cells to signal for more defenders.

(Image: Courtesy of Jianing Bai) 

Delivering a one-two punch to superbugs to fight infections

Penn researchers create mirror-image molecules that both kill pathogens outright and rally the immune system—an advance aimed at the growing crisis of antimicrobial resistance.

3 min. read

AI x Science Postdoctoral Fellowship
Aerial shot of Amy Guttman Hall

Bhuvnesh Jain of the School of Arts & Sciences has teamed up with PIK University Professor René Vidal of the Perelman School of Medicine and the School of Engineering and Applied Science to create the AI x Science Fellowship offering postdoctoral researchers across the University opportunities to collaborate across disciplines.

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AI x Science Postdoctoral Fellowship

Bhuvnesh Jain and René Vidal have teamed up to create the AI x Science Fellowship, which builds on the thriving postdoctoral program of the Data Driven Discovery Initiative to foster cross-disciplinary collaboration among researchers across the University.

6 min. read

Performer, biomedical engineer, and soon-to-be graduate
Jordyn Harris standing among lights

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Performer, biomedical engineer, and soon-to-be graduate

A performer and dancer, fourth-year Jordyn Harris has been a work-study student for the Platt House and managed tech for myriad student shows, while also advising engineering first-years and working as a researcher at a hospital.

5 min. read

Microrobots navigate diverse oral environments to deliver therapies

Microrobots navigate diverse oral environments to deliver therapies

Penn Engineers and clinicians at the Center for Innovation & Precision Dentistry are developing shapeshifting microrobots capable of navigating the complex environments of the mouth to deliver targeted treatments.