Bioengineering

Wei Guo of the School of Arts & Sciences and colleagues from the Perelman School of Medicine, School of Veterinary Medicine, and School of Engineering and Applied Science have teamed up to uncover how solid tumors’ complicated microenvironments can manipulate cancer-fighting CAR T cells through extracellular vesicles, causing the engineered CAR T cells to commit fratricide—essentially turning against each other instead of attacking the cancer.

(Image: iStock / Marcin Klapczynski)

The researchers theorized that frogs must have developed antibiotics to survive in their challenging environment.

Image: Michael Edward via Getty Images

Kayla Gay, who teaches middle school in Northwest Philadelphia, spent the summer learning about lab techniques that she can bring back to her classroom.

(Image: Courtesy of Kayla Gay)

David Bakalov, center, hopes to leverage his Fellows experience to develop new medical treatments.

nocred

The Stentix team (top) Summer Cobb and Amanda Kossoff, (bottom) Aarsha Shah and Elizabeth Jia, with judges (descending left) Matt Fitz-Henry, Jason Smith, Jennifer Gilburg, and Sasha Schrode, and (descending right) David Hsu, Gerald Lopez, and Dean Miller.

(Image: Courtesy of the William and Phyllis Mack Institute for Innovation Management)

The new chip will allow for automated experiments, and can be connected to chip-based models of other organ systems, like the lungs.

(Image: Dan Huh)

A sample of the new lipids, which improve the success rate of lipid nanoparticles delivering their contents.

(Image: Sylvia Zhang)