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Bioengineering
More cancers may be treated with drugs than previously believed
More cancers may be treated with drugs than previously believed
Using a Penn-designed neural network called PocketMiner, a Penn Medicine research team has identified hidden protein pockets that can provide new opportunities for cancer drugs to bind to.
A potential strategy to improve T cell therapy in solid tumors
A potential strategy to improve T cell therapy in solid tumors
A new Penn Medicine preclinical study finds that a new simultaneous “knockout” of two inflammatory regulators boosted T cell expansion to attach solid tumors.
Targeted prenatal therapy addresses long-standing gap in health equity
Targeted prenatal therapy addresses long-standing gap in health equity
Penn engineers have developed a successful delivery system of mRNA to placental cells to treat preeclampsia at its root.
New insights into the mechanisms of tumor growth
New insights into the mechanisms of tumor growth
A team of researchers led by the School of Arts & Science’s Wei Guo characterize the molecular pathways that play a major role in tumorigenesis, findings that could lead to better diagnostic tools for cancer and new targeted therapies.
RNA lipid nanoparticle engineering stops liver fibrosis in its tracks
RNA lipid nanoparticle engineering stops liver fibrosis in its tracks
A successful lipid nanoparticles drug delivery system targets notoriously hard-to-target activated fibroblasts in the liver.
OCTOPUS, an optimized device for growing mini-organs in a dish
OCTOPUS, an optimized device for growing mini-organs in a dish
With OCTOPUS, Dan Huh’s team expands organoid research with a platform superior to conventional gel droplets, allowing researchers to replicate biological systems outside of the body.
New cell characterization method hints at reasons for resistance to cancer therapies
New cell characterization method hints at reasons for resistance to cancer therapies
Penn experts have developed new analysis tool that combines a cell’s unique gene expression data with information about the cell’s origins. The method can be applied to identify new cell subsets throughout development and better understand drug resistance.
Penn Libraries dedicates Holman Biotech Commons
Penn Libraries dedicates Holman Biotech Commons
The Commons serves as a collaborative resource for researchers in the health sciences, providing the latest tools and technologies to further health care research and equality.
Deconstructing the mechanics of bone marrow disease
Deconstructing the mechanics of bone marrow disease
A new understanding of how mechanical features of bone marrow affect resident immune cells in a fibrotic cancer points to future therapeutic strategies for cancers and fibrotic diseases.
Shapeshifting microrobots can brush and floss teeth
Shapeshifting microrobots can brush and floss teeth
In a proof-of-concept study, researchers from the School of Dental Medicine and School of Engineering and Applied Science shows that a hands-free system could effectively automate the treatment and removal of tooth-decay-causing bacteria and dental plaque.
In the News
Technical.ly Philly
Peek into an afternoon at Penn’s collaborative bioengineering lab and makerspace
A profile examines collaborative Penn projects at the George H. Stephenson Foundation Educational Laboratory and Bio-MakerSpace, with commentary by Sevile Mannickarottu of the School of Engineering and Applied Science.
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Inc.
Neuroscience explains why Bill Gates’ weird reading trick is so effective
A study by Penn researchers working in physics, neuroscience, and bioengineering found that people instinctively seek patterns and similarities in the data they absorb.
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Bloomberg
Havana Syndrome is a mystery, but not of physics
Ken Foster of the School of Engineering and Applied Science says that microwaves can stimulate the cochlea and cause people to hear a clicking sound known as the Frey effect.
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GEN Edge
Preeclampsia treated via protein replacement therapy in mice
A team led by Ph.D. student Kelsey Swingle in Michael Mitchell’s lab at the School of Engineering and Applied Science has developed an ionizable lipid nanoparticle formation that can deliver mRNA to placental cells to treat a serious pregnancy-related condition.
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Cosmos Magazine
Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall
Shu Yang of the School of Engineering and Applied Science and colleagues have developed a wooden seed carrier that can improve the germination rates of aerial seeding in areas that are difficult to access.
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Cosmos Magazine
Go bury yourself: Engineers design wooden seed carriers that drill down in the soil when exposed to rainfall
Shu Yang of the School of Engineering and Applied Science and colleagues have developed a wooden seed carrier that can improve the germination rates of aerial seeding in areas that are difficult to access.
FULL STORY →