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Bioengineering
Borrowing nature’s blueprint: How scientists replicated bone marrow
Borrowing nature’s blueprint: How scientists replicated bone marrow
A collaborative research team from Penn Engineering, Penn Medicine, and the Children’s Hospital of Philadelphia have developed a chip that mimics human bone marrow.
BEND lipids improve LNP mRNA delivery and gene editing
BEND lipids improve LNP mRNA delivery and gene editing
Penn Engineering researchers have developed a new class of lipids called branched endosomal disruptor (BEND) lipids to better deliver mRNA and gene-editing tools.
Breakthroughs in gene editing and expression control with mvGPT
Breakthroughs in gene editing and expression control with mvGPT
Penn Engineers have created a gene editing tool that can address different genetic diseases in the same cell.
Penn Center for Innovation celebrates 10 years
Penn Center for Innovation celebrates 10 years
The University’s nexus for technology transfer supports researchers in their innovative efforts, from CAR T to mRNA advancements that have dramatically reshaped the world.
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons
Unlocking the brain: Peptide-guided nanoparticles deliver mRNA to neurons
Researchers in the lab of Michael Mitchell in Penn Engineering have developed a method for delivering lipid nanoparticles across the blood-brain barrier specifically to targeted neurons.
How fungi make a key medicinal molecule
How fungi make a key medicinal molecule
New research from Penn Medicine has uncovered the catalyst that creates a compound in fungi whose derivatives are applied to treatments for cancer and inflammation.
Brain research could help patients with paralysis move again
Brain research could help patients with paralysis move again
Penn Medicine researchers are using machine learning to study the areas of the brain that control movement.
A lipid nanoparticle delivers an mRNA cure for preeclampsia
A lipid nanoparticle delivers an mRNA cure for preeclampsia
Doctoral student Kelsey Swingle developed a lipid nanoparticle that delivers an mRNA therapeutic that reduces maternal blood pressure through the end of gestation and improves fetal health and blood circulation in the placenta.
Refining lipid nanoparticles for better mRNA therapies
Refining lipid nanoparticles for better mRNA therapies
A new method developed by Penn engineers for designing ionizable lipids is expected to have broad implications for mRNA-based vaccines and therapeutics.
Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar
Penn fourth-year Om Gandhi is a 2025 Rhodes Scholar
Penn fourth-year Om Gandhi, from Barrington, Illinois, has been awarded a 2025 Rhodes Scholarship, which funds tuition and a living stipend for graduate study at the University of Oxford in England. He is among 32 American Rhodes Scholars, and an expected 100 worldwide.
In the News
HealthDay
In mouse studies, new hope against a dangerous complication of pregnancy
Doctoral student Kelsey Swingle in the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.
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New Scientist
Pre-eclampsia could be treated with mRNA technology
Michael Mitchell and Ph.D. student Kelsey Swingle of the School of Engineering and Applied Science and colleagues are using mRNA molecules to treat pre-eclampsia, a common pregnancy complication.
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Axios
Real vs. fake Christmas trees: The great debate, explained
Lorena Grundy of the School of Engineering and Applied Science says that the debate between real and fake Christmas trees isn’t as black and white as it’s being portrayed.
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Rolling Stone
RFK Jr.’s 10 wildest medical theories
Kenneth R. Foster of the School of Engineering and Applied Science says studies haven’t provided clear evidence that exposure to levels of radio frequency energy below accepted limits, such as Wi-Fi, disrupts the blood-brain barrier.
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Nature
Gut microbes’ genomes are a trove of potential antibiotics
Marcelo Torres of the School of Engineering and Applied Science and colleagues are synthesizing antibiotic microbes from microbiomes in the human gut.
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Pittsburgh Post-Gazette
Smart meter debate: Small group of consumers pushes against a meter mandate in Pennsylvania
Kenneth Foster of the School of Engineering and Applied Science says that the most reliable conclusions are always those of expert panels that conduct systematic reviews according to established procedures.
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