5/18
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Bone Marrow Protein May Be Target for Improving Stem Cell Transplants
Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.
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Diabetes Causes Shift in Oral Microbiome That Fosters Periodontitis, Penn Study Finds
A new study led by University of Pennsylvania researchers has found that the oral microbiome is affected by diabetes, causing a shift to increase its pathogenicity. The research, published in the journal Cell Host & Microbe this week, not only showed that the oral microbiome of mice with diabetes shifted but that the change was associated with increased inflammation and bone loss.
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Penn Wharton China Center Reflects Upon Two Years of Progress and Growth
On launching the Penn Wharton China Center in Beijing, in March of 2015, University of Pennsylvania President Amy Gutmann said, “We are building on Penn's history of broad, deep engagement with China and creating a Center that provides an impressive infrastructure and significant resources to augment Penn's many collaborations and partnerships with great Chinese educational
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‘Quarterbacks of dentistry’ now in training at Penn
With 178 million Americans missing at least one tooth, and 35 million missing all of their teeth, there is a great need for the work of prosthodontists, dentists who provide specialized care to replace missing or damaged teeth, or other structures in and around the mouth. Yet Pennsylvania has never before had a training ground for prosthodontics—one of the nine specialties recognized by the American Dental Association.
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Penn Study: Blocking Yeast-Bacteria Interaction May Prevent Severe Biofilms That Cause Childhood Tooth Decay
Though most tooth decay can be blamed on bacteria, such as Streptococcus mutans, the fungus Candida albicans may be a joint culprit in an alarmingly common form of severe tooth decay affecting toddlers known as early childhood caries.
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University of Pennsylvania to Celebrate Launch of Penn Center for Health, Devices and Technology
On May 2, 2017, the University of Pennsylvania will celebrate the launch of the Penn Center for Health, Devices and Technology, or Penn Health-Tech, a University-wide effort to advance Penn’s world-class breakthroughs into new devices and health technologies to meet the world’s most pressing health care needs. Marking the opening of the Center, the University will host the first in a series of regular symposia.
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Penn Team Characterizes the Underlying Cause of a Form of Macular Degeneration
Named for Friedrich Best, who characterized the disease in 1905, Best disease, also known as vitelliform macular dystrophy, affects children and young adults and can cause severe declines in central vision as patients age. The disease is one in a group of conditions known as bestrophinopathies, all linked to mutations in the BEST1 gene. This gene is expressed in the retinal pigment epithelium, or RPE, a layer of cells that undergirds and nourishes photoreceptor cells, the rods and cones responsible for vision.
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Penn Dental Medicine Professor Unlocks the Mysteries of Mast Cells
Mast cells, components of the immune system, are responsible for alleriges and asthma, conditions that debilitate millions. Yet relatively few scientists study them.
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Plant-made Hemophilia Therapy Shows Promise, Penn Study Finds
People with hemophilia require regular infusions of clotting factor to prevent them from experiencing uncontrolled bleeding. But a significant fraction develop antibodies against the clotting factor, essentially experiencing an allergic reaction to the very treatment that can prolong their lives.
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Penn Study Finds Link Between HIV Treatment and Neuronal Degeneration
Antiretroviral drugs have been life-changing therapies for HIV patients, but they can have significant side effects.Mounting evidence has implicated these drugs in contributing to HIV-associated neurocognitive disorders, or HAND, which can be manifested as forgetfulness, confusion and behavioral and motor changes. Yet an explanation for how the drugs take a toll on the brain has been lacking.