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Personalized Vaccine for Lymphoma Patients Extends Disease-Free Survival by Nearly Two Years
(ORLANDO, Fla.) –A personalized vaccine is a powerful therapy to prevent recurrence among certain follicular lymphoma patients, according to the latest results of ongoing research led by the University of Pennsylvania School of Medicine.
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Not Only Skin Deep: Penn Study on Skin Formation Suggests Strategies to Fight Skin Cancer
PHILADELPHIA - In a study published in the journal Developmental Cell, Sarah Millar PhD, professor of Dermatology and Cell & Developmental Biology at the University of Pennsylvania School of Medicine, and colleagues demonstrate that a pair of enzymes called HDACs are critical to the proper formation of mammalian skin.
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Color-Changing “Blast Badge” Detects Exposure to Explosive Shock Waves
PHILADELPHIA - Mimicking the reflective iridescence of a butterfly's wing, investigators at the University of Pennsylvania School of Medicine and School of Engineering and Applied Sciences have developed a color-changing patch that could be worn on soldiers' helmets and uniforms to indicate the strength of exposure to blasts from explosives in the field.
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First Blood Test to Determine Cognitive Impairment in Parkinson’s Disease Developed at Penn
PHILADELPHIA –Researchers at the University of Pennsylvania School of Medicine’s Udall Center for Parkinson's Research have developed the first blood-based biomarker test to predict cognitive decline in Parkinson’s disease (PD). If results can be replicated and standardized in other Parkinson patients, by other investigators, the test could be a useful tool to use in selecting patients for the development of new drugs that can slow or prevent this complication of the disease.
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Process Leading to Protein Diversity in Cells Important for Proper Neuron Firing
PHILADELPHIA – Cells have their own version of the cut-and-paste editing function called splicing. Researchers at the University of Pennsylvania School of Medicine have documented a novel form of splicing in the cytoplasm of a nerve cell, which dictates a special form of a potassium channel protein in the outer membrane. The channel protein is found in the dendrites of hippocampus cells -- the seat of memory, learning, and spatial navigation -- and is involved in coordinating the electrical firing of nerve cells.
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Penn Study: Hospital CPR Quality Is Worse at Night
CHICAGO -- CPR quality is worse during in-hospital cardiac arrests occurring overnight than those that happen during the day, according to a new University of Pennsylvania School of Medicine study that will be presented at the American Heart Association's annual Scientific Sessions on November 14.
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Penn-Led International Study Finds No Difference in Nonsuicide Mortality Between Two Anti-Psychotic Drugs
PHILADELPHIA - The potential for harmful side effects associated with anti-psychotic medications for treating schizophrenia is a frustration for mental-health professionals who must balance this with the positive benefits of drugs. For example, the issue of the antipsychotic drug ziprasidone lengthening the QTc interval, a possible indicator of life-threatening heart arrhythmias, has demanded much attention among clinicians since the drug was introduced in 2001.
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By Focusing on Reducing Disease Risk, “Desktop Medicine” will Transform the Practice of Medicine
Gone are the days when a doctor’s only way of helping patients is by treating the disease after symptoms have started. Instead, a new approach to medicine, called “Desktop Medicine” is emerging, in which the emphasis shifts from diagnosing diseases and treating symptoms to identifying risk-factors for medical conditions such as hypertension and osteoporosis, and intervening before they develop. The commentary appears in the current issue of the Journal of the American Medical Association.
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Penn Scientists Identify New Role for Protein Molecule That Inhibits Response of Immune-System Cells
PHILADELPHIA -– Researchers at the University of Pennsylvania have identified a new role for a protein molecule that inhibits the response of immune-system cells to inflammatory signals associated with many human diseases.
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Breast Cancer Survivors Often Rate Post-Treatment Breast Appearance Only “Fair”
SAN DIEGO -- A third of breast cancer survivors who received the breast-conserving treatments lumpectomy and radiation rate the appearance of their post-treatment breast as only “fair” or “poor” in comparison to their untreated breast, according to a new University of Pennsylvania School of Medicine study that will be presented today at the 52nd Annual Meeting of the American Society for Radiation Oncology (ASTRO) in San Diego.