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Penn Study Shows Two-Sided Immune Cell Could Be Harnessed to Shrink Tumors
PHILADELPHIA - A recently identified immune cell that directs other cells to fight infection plays a critical role in regulating the immune system in both health and disease. Researchers from the University of Pennsylvania School of Medicine have discovered how a stimulatory molecule and a protein found on the membrane of another immune cell make T helper 17 cells multi-taskers of sorts.
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Targeted Radiation Therapy Minimizes GI Side Effects for Prostate Cancer Patients, Penn Study Shows
SAN DIEGO -- Prostate cancer patients who receive intensity modulated radiation therapy (IMRT) are less apt to suffer serious gastrointestinal complications following their treatment than those who receive three-dimensional conformal radiotherapy (CRT), according to new research from the University of Pennsylvania School of Medicine. The study, which will be presented Nov.
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Is Sleepiness in Genes? Penn Medicine Study Shows Gene Variant Leaves Carriers Fatigued, Sleepier
Healthy sleepers who carry a specific gene variant are more likely to have disrupted sleep, according to University of Pennsylvania study published in the October 26, 2010 issue of Neurology®, the medical journal of the American Academy of Neurology.
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University of Pennsylvania Scientists Develop Method for Detecting MicroRNA From Living Cells
PHILADELPHIA -– Researchers at the University of Pennsylvania have developed a new electronic method for detecting microRNA isolated from living cells. MicroRNAs are a class of small biomolecules that control gene expression into proteins, the “workers” of the cell. MicroRNAs act by binding to specific messenger RNAs that code for proteins, and, by doing so, inhibit protein synthesis.
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Penn Study Identifies Molecular Guardian of Cell's RNA
When most genes are transcribed, the nascent RNAs they produce are not quite ready to be translated into proteins - they have to be processed first. One of those processes is called splicing, a mechanism by which non-coding gene sequences are removed and the remaining protein-coding sequences are joined together to form a final, mature messenger RNA (mRNA), which contains the recipe for making a protein.
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Penn Study Shows School-Based Program Reduces Risky Sexual Behaviors in South African Teens
A school-based, six-session program targeting sexual risk behaviors has proven effective in reducing rates of self-reported unprotected sex and sex with multiple partners among South African sixth-graders, according to a report in the October issue of Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.
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Is Team Science Productive? Penn Study Measures the Collaborative Nature of Translational Medicine
Taking a cue from the world of business-performance experts and baseball talent scouts, Penn Medicine translational medicine researchers are among the first to find a way to measure the productivity of collaborations in a young, emerging institute. They published their findings the most recent issue of Science Translational Medicine.
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Penn Study Gives Hope for New Class of Alzheimer’s Disease Drugs
Finding a drug that can cross the blood-brain barrier is the bane of drug development for Alzheimer’s disease and other neurological disorders of the brain. A new Penn study, published this week in the Journal of Neuroscience, has found and tested in an animal model of Alzheimer’s disease a class of drug that is able to enter the brain, where it stabilizes degenerating neurons and improves memory and learning.
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Shifting Forms: Penn Study Shows How Variations of Same Protein Affect Immune Response
How a T cell decides to make protein X, Y, or Z can have profound effects for fighting foreign invaders or staving off dire autoimmune reactions. Researchers at the University of Pennsylvania School of Medicine have identified the steps that control how different forms of an immune cell protein called CD45, which is critical for activating the immune system when faced with pathogens, are controlled in the arc of a body’s immune response.
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Penn’s Abramson Cancer Center Hailed as 'Exceptional' by the National Cancer Institute
The University of Pennsylvania’s Abramson Cancer Center has been rated as “exceptional” by the National Cancer Institute (NCI) during a competitive research funding review by the government agency.