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Perelman School of Medicine
Genetic switch turns tumor suppressor into oncogene in colorectal cancer
Researchers from the School of Veterinary Medicine have shown that an enzyme that suppresses early-stage colorectal cancer switches to become an oncogene as the cancer progresses.
A link between memory and appetite in the brain to explain obesity
Penn Medicine researchers have found the hippocampal subnetwork, located within the memory center of the brain, is more dysregulated in patients with higher body mass indexes, leading to an inability to control or regulate eating habits.
An immunotherapy strategy against all blood cancers
Researchers at Penn Medicine have demonstrated a new potential treatment using CAR T cell therapy using a CRISPR base-editing to develop a method called “epitope editing.”
Trading decisions are observable in the eyes of buyers and sellers
In a new collaborative study, PIK Professor Michael Platt models how the decision-making process unfolds in the brains of buyers and sellers considering a deal. These decisions were observable in eye movements and pupil dilation.
A summer studying the aesthetic brain
For third-year Olivia Kim, a PURM research experience with Penn neuroscientist Anjan Chatterjee allowed her to combine her love of neuroscience and art in a working lab.
Carl June on the boundless potential of CAR T cell therapy
In a Q & A, June, the Richard W. Vague Professor in Immunotherapy, and Daniel Baker, a fourth-year doctoral student in Penn’s Cell and Molecular Biology department, discuss how the treatment can extend to treating diseases beyond cancer.
Chasing the mysteries of microbiome communication in our bodies
Penn Medicine’s Maayan Levy and Christoph Thaiss, both assistant professors of microbiology, pursue an understanding of the the microbiome, the entirety of microbial organisms associated with the human body, and its relation to fundamental bodily systems.
For a new generation of antibiotics, scientists are bringing extinct molecules back to life
Marrying artificial intelligence with advanced experimental methods, Penn Engineering’s Machine Biology Group has mined the ancient past for future medical breakthroughs, bringing extinct molecules back to life.
SCALAR: A microchip designed to transform the production of mRNA therapeutics and vaccines
Researchers have developed a platform that could rapidly accelerate the development of mRNA-based lipid nanoparticle vaccines and therapeutics at both the small and largescale, SCALAR.
Long-awaited accolades for mRNA scientists Katalin Karikó and Drew Weissman
Katalin Karikó and Drew Weissman’s key mRNA discoveries more than 15 years earlier made COVID vaccines possible. Now the global public has opportunities to honor them.
In the News
Man does DNA test, not prepared for what comes back ‘unusually high’
César de la Fuente of the School of Engineering and Applied Science and Perelman School of Medicine says that Neanderthal DNA provides insights into human evolution, population dynamics, and genetic adaptations, including correlations with traits such as immunity and susceptibility to diseases.
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Rural jails turn to community health workers to help the newly released succeed
According to Aditi Vasan of the Leonard Davis Institute and Perelman School of Medicine, evidence is mounting in favor of the model of training community health workers to help their neighbors connect to government and health care services.
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What is food noise and how do you get rid of it?
According to Thomas Wadden of the Perelman School of Medicine, people taking GLP-1 drugs are finding that daily experiences that used to trigger a compulsion to eat or think about food no longer have that effect.
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How to die in good health
PIK Professor Ezekiel Emanuel says that incessantly preparing for old age mistakes a long life for a worthwhile one.
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Mayor Parker’s plan to ‘remove the presence of drug users’ from Kensington raises new questions
Shoshana Aronowitz of the School of Nursing and Ashish Thakrar of the Perelman School of Medicine comment on the lack of specificity in Philadelphia’s plan to remove drug users from Kensington and on the current state of drug treatment in the city.
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