Health Sciences

Penn Medicine: Targets of Anticancer Drugs Have Broader Functions than What Their Name Suggests

Drugs that inhibit the activity of enzymes called histone deacetylases (HDACs) are being widely developed for treating cancer and other diseases, with two already on the market. Researchers at the Perelman School of Medicine, University of Pennsylvania, show that a major HDAC still functions in mice even when its enzyme activity is abolished, suggesting that the beneficial effects of HDAC inhibitors may not actually be through inhibiting HDAC activity, and thus warranting the reassessment of the molecular targets of this class of drugs.

Karen Kreeger



In the News


The New Yorker

How to die in good health

PIK Professor Ezekiel Emanuel says that incessantly preparing for old age mistakes a long life for a worthwhile one.

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Philadelphia Inquirer

Mayor Parker’s plan to ‘remove the presence of drug users’ from Kensington raises new questions

Shoshana Aronowitz of the School of Nursing and Ashish Thakrar of the Perelman School of Medicine comment on the lack of specificity in Philadelphia’s plan to remove drug users from Kensington and on the current state of drug treatment in the city.

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Philadelphia Inquirer

How many patients would recommend their Philly-area hospital to family and friends? Check your local hospital

The Hospital of the University of Pennsylvania has been named one of the most recommended acute-care facilities by patients in the Philadelphia area.

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WHYY (Philadelphia)

Homeward bound: When a Penn Medicine nurse was diagnosed with uterine cancer, she turned to the service dogs she helped to train

A profile highlights Maria Wright of Penn Medicine Lancaster General Health, from her volunteer work connecting people with service dogs to her cancer diagnosis and her own journey applying for a service dog.

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Philadelphia Inquirer

UPenn medical school names first vice dean of AI

Mary Ritchie has been named the vice dean of artificial intelligence and computing at the Perelman School of Medicine. Mitchell Schnall has been named the first senior vice president for data and technology solutions at the University of Pennsylvania Health System.

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