Mysterious ‘nuclear speckle’ cell structures may help block cancers
A new study out of Penn Medicine shows that the tumor-suppressor protein p53 brings speckles and DNA together to boost gene expression.
Gene therapy shows promise in initial trial for patients with childhood blindness
Penn Medicine researchers delivered working copies of the gene GUCY2D to the eyes of patients with severe vision impairments.
Study suggests those who had COVID-19 may only need one vaccine dose
People who have recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, therefore only a single dose may be needed to produce a sufficient antibody response, according to new research from the Penn Institute of Immunology.
Medication access for opioid use disorder lower among those in criminal justice system
Penn Medicine research finds Medicaid expansion helps increase access to medications for opioid use disorder, but limitations exist to broadening access.
Penn Medicine awarded nearly $7 million to study influenza viruses
Penn Medicine is one of five institutions in the U.S. chosen by the National Institutes of Health as a Center of Excellence for Influenza Research and Response to improve pandemic preparedness.
Living in a majority-Black neighborhood linked to severe maternal morbidity
Penn Medicine researchers studied the association between neighborhood-level risk factors and poor maternal health outcomes in Philadelphia between 2010 and 2017.
Cancer cell therapy pioneer Carl June receives the Sanford Lorraine Cross Award
The Richard W. Vague Professor in Immunotherapy in the department of Pathology and Laboratory Medicine in the Perelman School of Medicine and director of the Center for Cellular Immunotherapies at Penn’s Abramson Cancer Center received the award for his work in developing chimeric antigen receptor (CAR) T cell therapy.
With impressive accuracy, dogs can sniff out coronavirus
In a proof-of-concept study led by the School of Veterinary Medicine, dogs identified positive samples with 96% accuracy.
Immune-stimulating drug before surgery shows promise in early-stage pancreatic cancer
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments.
Racial bias in mortality prediction scores
In mass casualty situations like the COVID-19 pandemic, mortality prediction models alone could divert scarce critical care resources away from Black patients.
In the News
Your COVID post-vaccine activities safety guide, including gyms, shopping, taking an Uber and more
Once two weeks have passed following a second COVID-19 vaccine dose (or one Johnson & Johnson dose), individuals are considered fully vaccinated. At that point , what activities are considered “safe” to resume? Meenakshi Bewtra of the Perelman School of Medicine says that for vaccinated people, activities that were once considered risky are safer, but advises people to proceed with caution in light of new variants, and to keep public health and safety at the forefront of daily activities by wearing a mask and maintaining social distance in public.
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The immune link between a leaky blood-brain barrier and schizophrenia
For people with schizophrenia and other mental disorders, a more permissive blood-brain barrier appears to allow the immune system to get improperly involved in the central nervous system. The inflammation that arises likely contributes to the clinical manifestations of neuropsychiatric conditions, according to new findings from a team led by researchers from the School of Veterinary Medicine, Perelman School of Medicine, and Children’s Hospital of Philadelphia (CHOP).
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Earth Week: New research links lung cancer to air pollution in Philadelphia
Air in the Philadelphia region is ranked as the 12th most polluted in the country by the American Lung Association. Toxins in the air, mainly from traffic and industry, are known to cause lung cancer. Trevor Penning, a pharmacology professor in the Perelman School of Medicine, developed hazard indices for 421 zip codes using satellite imagery for particulate matter and volatile organic compounds.
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I’m a doctor who examines asylum seekers. I want Biden to fix the asylum system
Jules Lipoff of the Perelman School of Medicine argued for reforming and expanding the U.S. asylum system. “We must renew the United States as a bold world leader in standing for the dignity of human rights,” he wrote.
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Vaccine etiquette: A guide to politely navigating this new phase of the pandemic
Carolyn Cannuscio of the Perelman School of Medicine spoke about how people justify engaging in unsafe behaviors during the pandemic. “People are looking for the magical loopholes that they can step through so that they can return to their free and rich and rewarding social world,” she said. “And we’re not there.”
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