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Penn Study Decodes Molecular Mechanisms Underlying Stem Cell Reprogramming
PHILADELPHIA — Fifty years ago, UK researcher John Gurdon demonstrated that genetic material from non-reproductive cells could be reprogrammed into an embryonic state when transferred into an egg. In 2006, Kyoto University researcher Shinya Yamanaka expanded on those findings by expressing four proteins in mouse somatic cells to rewind their genetic clocks, converting them into embryonic-like stem cells called induced pluripotent stem cells, or iPS cells.
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Staff Q&A with Jonathan Fiene
Jonathan Fiene’s office is adorned with posters of his favorite sporting events and festivals from the past five years. But these posters don’t feature superstar athletes or rock gods; they highlight an assortment of student-built robots, most of which could fit inside a coffee can.
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El Yunque Rock, an Icon of Puerto Rico, Is Eroding More Slowly Than Expected, Penn Geologists Discover
PHILADELPHIA — El Yunque rock is a majestic, anvil-shaped promontory that has been an icon of the island of Puerto Rico since pre-Columbian times. The barren rock, standing 3,412 feet high, protrudes above primary old growth forest and is enshrouded in clouds, swept constantly by the trade winds and frequently stricken by hurricanes. The rock receives an average of three rain showers a day and more than 14 feet of rain every year. Given Puerto Rico’s warm and dynamic tropical climate, El Yunque should be covered with vegetation and eroding rapidly.
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The Shoah, remembered
The Shoah Foundation has its roots in Poland, once home to the largest Jewish community in Europe. Of the 3.3 million Jews who lived there before the Nazi invasion in 1939, 85 percent (more than 4 out of 5) were murdered during the Holocaust. While shooting the Academy Award-winning film “Schindler’s List” in Krakow in 1993, director Steven Spielberg was approached by scores of Holocaust survivors longing to share their stories.
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Design review
Dan Garofalo, Penn’s environmental sustainability coordinator and senior facilities planner, has been named to the first Civic Design Review Committee of the City of Philadelphia. The seven-member committee, mandated by the city’s new zoning code, will advise the City Planning Commission as it reviews development projects that have a significant impact on public streets, sidewalks, trails, parks, and open spaces.
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New Financial Aid Director Explains Penn’s No-loan Aid Program for Undergraduates
Joel Carstens, university director of financial aid at the University of Pennsylvania, may be new to campus, but he’s no stranger to the Ivy League and the financial-aid challenges of its schools and students. Formerly at Princeton University, Carstens joined Penn in September, ready to meet the challenges of serving undergraduate students at a much larger university and in an economy that is still fragile.
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Penn Study: Targeting Downstream Proteins in Cancer-Causing Pathway Shows Promise in Cell, Animal Model
PHILADELPHIA — The cancer-causing form of the gene Myc alters the metabolism of mitochondria, the cell’s powerhouse, making it dependent on the amino acid glutamine for survival. In fact, 40 percent of all “hard-to-treat” cancers have a mutation in the Myc gene.Accordingly, depriving cells of glutamine selectively induces programmed cell death in cells overexpressing mutant Myc.
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Penn Dental Medicine Receives $1.5 Million Grant to Support Student Scholarships
PHILADELPHIA — The University of Pennsylvania School of Dental Medicine has received a $1.5 million grant for student scholarships from the Health Resources and Services Administration of the U.S. Department of Health and Human Services.
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Penn World Scholar Student Continues Life of Public Service That Began in Egypt
Applying to colleges is a hard enough task, but it was made even more difficult for Diana Gonimah when the political turmoil of Arab Spring in her home country, Egypt, briefly shut down communication with the outside world. Her high school closed for 20 days and she was barely able to call admissions officers in the U.S. to say, “Sorry, I can’t send my transcript for another month.”
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It's Not Just What You Eat, But When You Eat It: Penn Study Shows Link Between Fat Cell and Brain Molecules
PHILADELPHIA — Fat cells store excess energy and signal these levels to the brain.