New Findings on Drug Tolerance in Tuberculosis Suggest Ideas for Shorter Cures
New research on how tuberculosis (TB) bacteria develop multi-drug tolerance points to ways TB infections might be cured more quickly. The study was published online last week in Cell. The results identify both a mechanism and a potential therapy for drug tolerance that is induced in the TB bacteria by the host cells they infect. Currently, TB treatment requires a complex, long-term curative regimen of at least six months. Researchers at the University of Pennsylvania School of Medicine and the University of Washington described the existence of multi-drug tolerant bacteria that form within days of infection in zebrafish, an animal model for studying TB.
OpenAI, DeepSeek, and Google vary widely in identifying hate speech
Neil Fasching and Yphtach Lelkes of the Annenberg School for Communication have found dramatic differences in how large language models classify hate speech, with especially large variations for language about certain demographic groups, raising concerns about bias and disproportionate harm.
Understanding order to disorder at the atomic scale opens possibilities for next-generation electronic devices
A Penn team has developed insight into the chemical and geometric mechanisms underlying the synthesis of new 2D materials, paving the way for next-gen devices, biomedical applications, and cleaner, quicker energy conversion and storage.
(From left) Kevin B. Mahoney, chief executive officer of the University of Pennsylvania Health System; Penn President J. Larry Jameson; Jonathan A. Epstein, dean of the Perelman School of Medicine (PSOM); and E. Michael Ostap, senior vice dean and chief scientific officer at PSOM, at the ribbon cutting at 3600 Civic Center Boulevard.
Reimagined Penn Medicine facility set to usher in a bold new era of Immune Health discovery
3600 Civic Center Boulevard will bring together key researchers and technologies in Immune Health, the Colton Center for Autoimmunity, and infectious diseases to drive breakthrough science.
