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Articles from Karen Kreeger
Penn Research: Gatekeeper of Brain Steroid Signals Boosts Emotional Resilience to Stress

Penn Research: Gatekeeper of Brain Steroid Signals Boosts Emotional Resilience to Stress

A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania.

Karen Kreeger

Penn Study Cautions Use of Drugs to Block 'Niacin Flush' in Heart Patients

Penn Study Cautions Use of Drugs to Block 'Niacin Flush' in Heart Patients

Niacin, or vitamin B3, is the one approved drug that elevates "good" cholesterol (high density lipoprotein, HDL) while depressing "bad" cholesterol (low density lipoprotein , LDL), and has thereby attracted much attention from patients and physicians. Niacin keeps fat from breaking down, and so obstructs the availability of LDL building blocks.

Karen Kreeger

DNA Sequencing Consortium Finds Patterns of Mutations in Autism, Highlighting Potential Risk Factors

DNA Sequencing Consortium Finds Patterns of Mutations in Autism, Highlighting Potential Risk Factors

Researchers have long recognized that autism runs in families, suggesting a genetic component. Yet, few genes have so far been identified and the underlying genetic nature of autism — how many genes contribute and to what extent they influence a person's chances of developing the disorder — remains poorly understood.

Karen Kreeger

Penn Medicine Researchers Find that Molecular Pair Controls Time-Keeping and Fat Metabolism

Penn Medicine Researchers Find that Molecular Pair Controls Time-Keeping and Fat Metabolism

The 24-hour internal clock controls many aspects of human behavior and physiology, including sleep, blood pressure, and metabolism. Disruption in circadian rhythms leads to increased incidence of many diseases, including metabolic disease and cancer. Each cell of the body has its own internal timing mechanism, which is controlled by proteins that keep one another in check.

Karen Kreeger

Duality of Longevity Drug Explained by Penn Medicine Researchers

Duality of Longevity Drug Explained by Penn Medicine Researchers

A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively.

Karen Kreeger

Inner Weapons Against Allergies: Gut Bacteria Control Allergic Diseases, Penn Study Finds

Inner Weapons Against Allergies: Gut Bacteria Control Allergic Diseases, Penn Study Finds

When poet Walt Whitman wrote that we "contain multitudes," he was speaking metaphorically, but he was correct in the literal sense. Every human being carries over 100 trillion individual bacterial cells within the intestine -- ten times more cells than comprise the body itself.

Karen Kreeger

Potential Alzheimer's Drug Slows Damage and Symptoms in Animal Model, According to Penn Study

Potential Alzheimer's Drug Slows Damage and Symptoms in Animal Model, According to Penn Study

A study published this week in the Journal of Neuroscience shows that the compound epothilone D (EpoD) is effective in preventing further neurological damage and improving cognitive performance in a mouse model of Alzheimer's disease (AD). The results establish how the drug might be used in early-stage AD patients.

Karen Kreeger

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