4/22
Penn Biochemist Receives Protein Society Award
Benjamin Aaron Garcia, PhD, a Presidential Professor of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania, has been selected to receive the 2016Protein Science Young Investigator Award.
Penn Study Shows a Form of Genetically Elevated "Good" Cholesterol May Actually be Bad
The generally accepted medical maxim that elevated HDL cholesterol (HDL-C) is “good” has been overturned by a multi-center, international study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Blocking Transfer of Calcium to Cell's Powerhouse Selectively Kills Cancer Cells, Suggesting a New Way to Fight the Disease
Inhibiting the transfer of calcium ions into the cell’s powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Three Penn Researchers Awarded 2016 Sloan Fellowships
Three University of Pennsylvania faculty members are among recipients of this year’s Sloan Research Fellowship, two from Penn’s Perelman School of Medicine, one from Penn’s
New Mathematical Model Explains Variability in Mutation Rates Across the Human Genome
It turns out that the type, how frequent, and where new mutations occur in the human genome depends on which DNA building blocks are nearby, found researchers from the Perelman School of Medicine at the University of Pennsylvania in an advanced online study
Penn Study Prompts Reevaluation of Assumptions on Role of Internal Clock in Human Disease
Abolishing the 24-hour clock by knocking out a key gene during development accelerates aging and shortens lifespan by two thirds in mice, but this effect is absent if the gene deletion is delayed until after birth, according to a new study published this week in Science Translational Medicine by scientists from the Perelman School of Medicine at the University of Pennsylvania.
"Gene Fusion" Mutation Uses Three-Way Mechanism To Drive Childhood Brain Cancers
A powerful, three-way mechanism by which a mutation drives the growth of childhood brain cancers, was discovered by scientists from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP).
Penn Study Identifies Enzyme Key to Link Between Age-Related Inflammation and Cancer
For the first time, researchers have shown that an enzyme key to regulating gene expression -- and also an oncogene when mutated -- is critical for the expression of numerous inflammatory compounds that have been implicated in age-related increases in cancer and tissue degeneration, according to new research from the Perelman School of Medicine at the University of Pennsylvania. Inhibitors of the enzyme are being developed as a new anti-cancer target.
Viral Gene Editing System Corrects Genetic Liver Disease in Newborn Mice
For the first time, researchers have treated an animal model of a genetic disorder using a viral vector to deliver genome-editing components in which the disease- causing mutation has been corrected. Delivery of the vector to newborn mice improved their survival while treatment of adult animals, unexpectedly, made them worse, according to a new study by investigators from the Perelman School of Medicine at the University of Pennsylvania The team published their findings this week in Nature Biotechnology.
Powerful Machine-Learning Technique Uncovers Unknown Features of Important Bacterial Pathogen, According to Penn Study
A powerful new machine-learning technique can be applied to large datasets in the biological sciences to uncover previously unknown features of organisms and their genes, according to a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. For ex