Research led by Penn Vet scientists has revealed the gene underlying a form of night blindess that affects dogs. Dogs with the mutation in the LRIT3 gene (right panels) have less of the resulting protein (labeled yellow-green) in the tips of the retina's ON-bipolar cells than unaffected dogs (left panels). (Image: Penn Vet)
Identifying a gene for canine night blindness
An international team of researchers led by the School of Veterinary Medicine’s Keiko Miyadera has identified the gene mutation responsible for a form of night blindness in dogs. Strategies to treat this condition could also inform treatment of other diseases that rely on targeting this cell type.
Vaping has been marketed as a safer alternative to smoking cigarettes, but recent deaths and acute respiratory illnesses have belied that claim. Pulmonologist and smoking cessation expert Frank Leone of the Perelman School of Medicine explains the e-cigarette phenomenon and why it’s dangerous.
An ambitious outdoor experiment in fruit flies at Pennovation Works revealed that an altered microbiome can drive evolutionary change. (Photo: Seth Rudman)
Fruit flies’ microbiomes shape their evolution
In just five generations, an altered microbiome can lead to genome-wide evolution in fruit flies, according to new research led by Paul Schmidt and postdoc Seth Rudman of the School of Arts and Sciences.
Canine retinas after successful gene augmentation therapy with RPE65 (red-labeling of the RPE cell layer). When eyes are treated at a stage when photoreceptor numbers are close to normal, there is an arrest of retinal degeneration, and cone (labeled in green) and rod photoreceptors retain normal structure for at least four years following treatment (upper image). If degeneration is ongoing at the time of treatment, there is substantial and progressive loss of photoreceptors in spite of robust RPE65 expression (lower image). (Image: Aguirre Laboratory/Penn Vet)
Is treatment forever? Success of gene therapy for inherited blindness depends on timing
An FDA-approved gene therapy for Leber congenital amaurosis, an inherited vision disorder with a childhood onset and progressive nature, has improved patients’ sight. But new research underscores the importance of further investigation to halt the progression of the disorder.
The diet-microbiome connection in inflammatory bowel disease
Dogs with a Crohn’s-like disease fed a special diet were found to have characteristic changes in their gut microbiomes, paralleling changes seen in children with Crohn’s.
Sensors on NASA satellites Terra and Aqua captured a record of thousands of points of fire in Brazil in late August. The fires pose a threat to the Amazon rainforest and to people living in and around it. (Image: NASA Earth Observatory)
Inferno in the rainforest
Satellite images have detected more than 100,000 points of fire in the Amazon this year. Scientists Reto Gieré and Alain Plante illuminate some less obvious impacts of the fires, including health threats and climate impacts.
Each cell of a developing nematode worm embryo is catalogued at the molecular level in a new paper out in Science. In this visualization of the dataset, each dot represents a single cell, its color represents the age of the embryo it came from (orange=early, green=mid, blue/red=late), and the dots are arranged so that cells with similar transcriptomes are near each other. Visualized this way, the data form various thin “trajectories” that correspond to tissues and individual cell types. (Image: Cole Trapnell)
A molecular ‘atlas’ of animal development
Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.
Information gerrymandering can change the way we think about political decisions, as depicted in this image of a gerrymandered mind. People must integrate disparate sources of information when deciding how to vote. But information does not always flow freely; it can be constrained by social networks and distorted by zealots and automated bots. Researchers showed that certain structures in a social network can sway the voting outcome of towards one party, even when both parties have equal size and each player has the same influence, a phenomenon they called “information gerrymandering." (Image: Alexander Stewart)
‘Information gerrymandering’ poses a threat to democratic decision making
Concern over fake news and online trolls is widespread and warranted, but researchers have identified another impediment to the free flow of information in social networks. The phenomenon, which they term “information gerrymandering,” arises from the structure of a social network and introduces bias into collective decisions.
No evidence that testosterone reduces cognitive empathy
In the largest study of its kind, researchers found that testosterone administration did not affect cognitive empathy, a measure of the ability to recognize another’s feelings and motivations. The finding calls into question the theory that the symptoms of autism are caused by a hyper-masculinized brain.
