Perelman School of Medicine

Casting one of the largest genomic nets to date for the rare tumors of the autonomic nervous system known as pheochromocytoma and paraganglioma (PCC/PGL) captured several new mutations driving the disease that could serve as potential drug targets, researchers from Penn Medicine and other institutions reported in 

Penn Medicine’s Orphan Disease Center (ODC) announces a new partnership with the Foundation for Angelman Syndrome Therapeutics or FAST to study gene therapy approaches to treat Angelman syndrome (AS).

Critically ill infants and children do not gain extra benefit from lower blood-sugar levels, compared to higher levels within the usual care range, according to research from the Children’s Hospital of Philadelphia, the University of Pennsylvania

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

Katalin Susztak, MD, PhD, an associate professor of Medicine and Genetics in the Perelman School of Medicine at the University of Pennsylvania, has received a $3 million grant from a consortium of pharmaceutical companies to identify genes and other characteristics that are signs of rapid decline in kidney function in patients with diabetic kidney disease.​​​​​​​

A new Zika vaccine candidate has the potential to protect against the virus with a single dose, according to a research team led by scientists from the Perelman School of Medicine at the University of Pennsylvania. As reported in Nature this week, preclinical tests showed promising immune responses in both mice and monkeys.

Depending on the specific type, bacteria in a woman’s vagina and cervix may increase the risk of premature birth or protect against it, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

Body shaming is a pervasive form of prejudice, found in cyber bullying, critiques of celebrities' appearances, at work and school, and in public places for everyday Americans. People who are battling obesity face being stereotyped as lazy, incompetent, unattractive, lacking willpower, and to blame for their excess weight.

Across the world, social media users leave a trail of clues about themselves each time they Tweet, post to Facebook, write a Yelp review, and apply a filter and hashtags to their latest Instagram photo. Under the leadership of Raina Merchant, MD, MSHP, researchers and physicians at Penn Medicine are mining those clues to find what ails them – and how to fix it.

Some of Penn Medicine’s biggest accomplishments included employing virtual reality devices to treat phantom limb pain, performing Penn’s third bilateral hand transplant, and using CRISPR to treat hemophilia in mice.