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11/26
Perelman School of Medicine
Penn Team Maps First Comprehensive Profile of Non-Protein-Coding RNAs to Provide Clinicians with New Way to Diagnose Array of Cancers
Growing insights about a significant, yet poorly understood, part of the genome – the “dark matter of DNA” -- have fundamentally changed the way scientists approach the study of diseases. The human genome contains about 20,000 protein-coding genes – less than 2 percent of the total – but 70 percent of the genome is made into non-coding RNA.
Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug, Providing New Target for Preventing Relapses, Finds Penn Study
A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug, found researchers at the Perelman School of Medicine at the University of Pennsylvania
Penn Study Stops Vision Loss in Late-stage Canine X-linked Retinitis Pigmentosa
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Cancer Doesn't Sleep: The Myc Oncogene Disrupts Circadian Rhythm and Metabolism in Cancer Cells, Finds New Penn Study
Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of senior author Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, study body clock proteins associated with cancer cells.
Penn Team Pinpoints Immune Changes in Blood of Melanoma Patients on PD-1 Drugs That Put Potential Biomarker within Reach
A simple blood test can detect early markers of “reinvigorated” T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
Multiple Myeloma Patients More Vulnerable to 'Financial Toxicity' Due to Expensive, Longer Courses of Treatments, Penn Study Finds
Even patients with health insurance who have multiple myeloma may be vulnerable to “financial toxicity” – including those who make over $100,000 a year – because of the higher use of novel therapeutics and extended duration of myeloma treatment, researchers from Penn’s Abramson Cancer Center report in this week’s
A History Student Makes an Impact in the Operating Room at Penn
It’s not only physicians and nurses who can make a difference in health care. Sometimes it takes a history major and some careful observation to help effect positive change.
Penn Study Demonstrates Genes' Major Role in Skin and Organ Development
Knocking out one or both crucial regulatory genes caused cleft lip, skin barrier defects, and a host of other developmental problems in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania, hinting that abnormalities in these molecular pathways could underlie many birth defects that are presently not well understood.
Blood Cancers Develop When Immune Cell DNA Editing Enzyme Hits Off-target Spots in the Genome, Penn Animal Study Finds
Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers.
Sensitivity of Smell Cilia Depends on Location and Length in Nasal Cavity, Penn Researchers Find
Like the hairs they resemble, cilia come in all lengths, from short to long. But unlike the hair on our heads, the length of sensory cilia on nerve cells in our noses is of far more than merely cosmetic significance.
In the News
Philadelphia Inquirer
Is there a chemical link to memory loss? Penn researchers get $11M to study dementia causes
The National Institutes of Health have awarded $11 million to Aimin Chen of the Perelman School of Medicine to study the link between chemical exposures and dementia.
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Philadelphia Inquirer
COVID patient who survived coma reunites with Penn care team
A COVID patient who survived his coma recently reunited with the Penn Medicine care team that helped save his life, including Jennifer Olenik of the Perelman School of Medicine.
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CNN
Vaping immediately affects vascular health and oxygen levels, study shows, even without nicotine
Research published by Marianne Nabbout while a resident at the Perelman School of Medicine finds that vaping has an immediate effect on blood vessels even if an e-cigarette doesn’t contain nicotine.
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Fox 29 (Philadelphia)
Former patient gives thanks to PA hospital staff after surviving coma, COVID-19 battle
A former COVID patient who spent six months in a coma returned to thank the Penn Medicine team that contributed to his survival, including Megan Carr-Lettieri.
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Forbes
Insomnia may be more common than you think. Here’s what to know
According to Penn Medicine, about 1 in 4 Americans experiences difficulty with sleep each year.
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