Perelman School of Medicine

Penn Medicine Researchers Pinpoint Potential New Drug Target for Protection against Certain Neurodegenerative Diseases

Penn Medicine researchers have discovered that hypermethylation - the epigenetic ability to turn down or turn off a bad gene implicated in 10 to 30 percent of patients with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD) - serves as a protective barrier inhibiting the development of these diseases.  Their work, published this month in Neurology, may suggest a neuroprotective target for drug discovery efforts.

Lee-Ann Donegan

Penn Researchers Describe New Approach to Promote Regeneration of Heart Tissue

The heart tissue of mammals has limited capacity to regenerate after an injury such as a heart attack, in part due to the inability to reactivate a cardiac muscle cell and proliferation program. Recent studies have indicated a low level of cardiac muscle cell (cardiomyocytes) proliferation in adult mammals, but it is insufficient to repair damaged hearts.

Karen Kreeger

Penn Medicine Study Finds Being Near Greened Vacant Lots Lowers Heart Rates

Greening vacant lots may be associated with biologic reductions in stress, according to a new study from the Perelman School of Medicine at the University of Pennsylvania. Residents who walked near newly greened vacant lots had significantly lower heart rates compared to walking near a blighted, or neglected, vacant lot.

Greg Richter

Two Penn Medicine Gene Therapy Researchers Receive Pennsylvania Bio Awards

Two researchers from the Perelman School of Medicine at the University of Pennsylvaniawill be honored for their contributions for the burgeoning field of gene therapy by Pennsylvania Bio at their annual dinner this week. Pennsylvania Bio is the statewide bioscience trade organization which works to make the Keystone State a life sciences hub by creating an environment which cultivates progress and success.

Paul Foster

Penn Medicine Analysis Shows that One-Third of Americans Do Not Have Access to Stroke Center Within One Hour

Stroke is one of the leading causes of death and disability in the United States, but access to rapid EMS care and appropriate stroke care centers with the ability to deliver acute stroke therapies can drastically mitigate the debilitating effects of a stroke. A population-based approach to health planning would prevent disparities in access to specialized stroke care, says new Penn Medicine research.

Lee-Ann Donegan

Twitter Chatter Predicts Health Insurance Marketplace Enrollment, Penn Study Shows

An increase in Twitter sentiment (the positivity or negativity of tweets) is associated with an increase in state-level enrollment in the Affordable Care Act’s (ACA) health insurance marketplaces — a phenomenon that points to use of the social media platform as a real-time gauge of public opinion and provides a way for marketplaces to quickly identify enrollment changes and emerging issues.

Anna Duerr

Penn Medicine: Gorilla Origins of the Last Two AIDS Virus Lineages Confirmed

Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists from the Perelman School of Medicine at the University of Pennsylvania, the University of Montpellier, the University of Edinburgh, and others.

Karen Kreeger



In the News


Fox 29 (Philadelphia)

Cannabis reclassification could be game-changer for U.S. drug policy

Michael Cirigliano of the Perelman School of Medicine says that marijuana deserves to be removed from the same category as LSD, heroin, and fentanyl.

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The Washington Post

Americans are sleeping more than ever. See how you compare

Mathias Basner of the Perelman School of Medicine says that work and traveling are the major sleep killers, with the majority of traveling being commuting to and from work.

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Newsweek

Man does DNA test, not prepared for what comes back ‘unusually high’

César de la Fuente of the School of Engineering and Applied Science and Perelman School of Medicine says that Neanderthal DNA provides insights into human evolution, population dynamics, and genetic adaptations, including correlations with traits such as immunity and susceptibility to diseases.

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Women’s Health

How does fat leave the body? Experts explain the weight loss process

Colleen Tewksbury of the School of Nursing and Perelman School of Medicine says that waist circumference is a more accessible and potentially more helpful measure for fat loss than stepping on a scale.

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Philadelphia Inquirer

Cardiac arrest recoveries are great stories, but they’re rare. We can fix that

In an opinion essay, Raina Merchant of the Perelman School of Medicine says that low survival rates for cardiac arrest can be improved by increasing rates of CPR.

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