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Perelman School of Medicine
Penn Medicine Researchers Show Brain Activity Can Predict Increased Fat Intake Following Sleep Deprivation
Experts have warned for years that insufficient sleep can lead to weight gain.
Immune Biomarkers Help Predict Early Death, Complications in HIV Patients with TB, Penn Study Finds
Doctors treating patients battling both HIV and tuberculosis (TB)—many of whom live in Africa—are faced with the decision when to start those patients on antiretroviral therapy (ART) while they are being treated with antibiotics for active TB disease.
Penn Medicine's New Immunotherapy Study Will Pit PD-1 Inhibitor Against Advanced Lung Cancer
Penn Medicine researchers have begun a new immunotherapy trial with the “checkpoint inhibitor” known as pembrolizumab in patients with oligometastatic lung cancer—a state characterized by a few metastases in a confined area—who have completed conventional treatments and are considered free of active disease but remain at a high risk for recurrence.
Sharp, Sustained Increases in Suicides Closely Shadowed Austerity Events in Greece, Penn Study Finds
Sharp and significant increases in suicides followed select financial crisis events and austerity announcements in Greece, from the start of the country’s 2008 recession to steep spending cuts in 2012, Penn Medicine researchers report in a new study published online this week in the British Medical Journal Open, along with colleagues from Greece and the United Kingdom.
Penn Center for Innovation Awarded NSF Grant to Foster Entrepreneurship
The Penn Center for Innovation, the University of Pennsylvania’s commercialization organization, announced today that it has been awarded a three-year grant from the National Science Foundation to establish an I-Corps Site to support translation of research areas into the marketplace by providing educational programming, financial support and strategic guidance.
Penn Researchers Show Value of Tissue-Engineering to Repair Major Peripheral Nerve Injuries
Peripheral nerve injury (PNI) is a common consequence of traumatic injuries, wounds caused by an external force or an act of violence, such as a car accident, gun shot or even surgery. In those injuries that require surgical reconstruction, outcomes can result in partial or complete loss of nerve function and a reduced quality of life. But, researchers at Penn Medicine have demonstrated a novel way to regenerate long-distance nerve connections in animal models using tissue-engineered nerve grafts (TENGs).
Penn Medicine Study Shows Menopause Does Not Increase or Create Difficulty Sleeping
Women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
Penn Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
Field Center at Penn Addresses America’s ‘Throwaway Children’ Through History
The Field Center for Children’s Policy, Practice & Research at the University of Pennsylvania will host a community symposium in conjunction with One Book, One Philadelphia, Monday, Feb. 9, at 8:30 a.m.
Penn Study Uncovers Secrets of a Clump-Dissolving Protein
Workhorse molecules called heat-shock proteins contribute to refolding proteins that were once misfolded and clumped, causing such disorders as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. James Shorter, PhD, an associate professor of Biochemistry and Biophysics, at the Perelman School of Medicine at the University of Pennsylvania, has been developing ways to "reprogram" one such protein – a yeast protein called Hsp104 -- to improve its therapeutic properties.
In the News
Fox 29 (Philadelphia)
Cannabis reclassification could be game-changer for U.S. drug policy
Michael Cirigliano of the Perelman School of Medicine says that marijuana deserves to be removed from the same category as LSD, heroin, and fentanyl.
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The Washington Post
Americans are sleeping more than ever. See how you compare
Mathias Basner of the Perelman School of Medicine says that work and traveling are the major sleep killers, with the majority of traveling being commuting to and from work.
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Newsweek
Man does DNA test, not prepared for what comes back ‘unusually high’
César de la Fuente of the School of Engineering and Applied Science and Perelman School of Medicine says that Neanderthal DNA provides insights into human evolution, population dynamics, and genetic adaptations, including correlations with traits such as immunity and susceptibility to diseases.
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Philadelphia Inquirer
Cardiac arrest recoveries are great stories, but they’re rare. We can fix that
In an opinion essay, Raina Merchant of the Perelman School of Medicine says that low survival rates for cardiac arrest can be improved by increasing rates of CPR.
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Women’s Health
How does fat leave the body? Experts explain the weight loss process
Colleen Tewksbury of the School of Nursing and Perelman School of Medicine says that waist circumference is a more accessible and potentially more helpful measure for fat loss than stepping on a scale.
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