Perelman School of Medicine

Penn Researchers Show Value of Tissue-Engineering to Repair Major Peripheral Nerve Injuries

Peripheral nerve injury (PNI) is a common consequence of traumatic injuries, wounds caused by an external force or an act of violence, such as a car accident, gun shot or even surgery. In those injuries that require surgical reconstruction, outcomes  can result in partial or complete loss of nerve function and a reduced quality of life. But, researchers at Penn Medicine have demonstrated a novel way to regenerate long-distance nerve connections in animal models using tissue-engineered nerve grafts (TENGs).

Lee-Ann Donegan

Penn Medicine Study Shows Menopause Does Not Increase or Create Difficulty Sleeping

Women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Katie Delach

Penn Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder

Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.

Karen Kreeger

Penn Study Uncovers Secrets of a Clump-Dissolving Protein

Workhorse molecules called heat-shock proteins contribute to refolding proteins that were once misfolded and clumped, causing such disorders as Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. James Shorter, PhD, an associate professor of Biochemistry and Biophysics, at the Perelman School of Medicine at the University of Pennsylvania, has been developing ways to "reprogram" one such protein – a yeast protein called Hsp104 -- to improve its therapeutic properties.

Karen Kreeger

Medicaid "Fee Bump" to Primary Care Doctors Associated with Better Access to Appointments, According to Penn Study

The increase in Medicaid reimbursement for primary care providers, a key provision of the Affordable Care Act (ACA), was associated with a 7.7 percentage points increase in new patient appointment availability without longer wait times, according to results of a new 10-state study — co-authored by researchers at the University of Pennsylvania and the Urban Institute, and funded by the Robert Wood Johnson Foundation — published online-first by the New England Journal of Medicine.

Anna Duerr

Penn Medicine Researchers Discover Possible New General Anesthetics

Penn Medicine researchers, in a continuation of their groundbreaking work to better understand how anesthesia works in the body, have found the first new class of novel anesthetics since the 1970s. Their findings, published in February issue of Anesthesiology, detail the processes through which the group uncovered these compounds.

Lee-Ann Donegan



In the News


CNN

Vaping immediately affects vascular health and oxygen levels, study shows, even without nicotine

Research published by Marianne Nabbout while a resident at the Perelman School of Medicine finds that vaping has an immediate effect on blood vessels even if an e-cigarette doesn’t contain nicotine.

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Fox 29 (Philadelphia)

Former patient gives thanks to PA hospital staff after surviving coma, COVID-19 battle

A former COVID patient who spent six months in a coma returned to thank the Penn Medicine team that contributed to his survival, including Megan Carr-Lettieri.

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Philadelphia Inquirer

Is there a chemical link to memory loss? Penn researchers get $11M to study dementia causes

The National Institutes of Health have awarded $11 million to Aimin Chen of the Perelman School of Medicine to study the link between chemical exposures and dementia.

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Philadelphia Inquirer

COVID patient who survived coma reunites with Penn care team

A COVID patient who survived his coma recently reunited with the Penn Medicine care team that helped save his life, including Jennifer Olenik of the Perelman School of Medicine.

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Forbes

Insomnia may be more common than you think. Here’s what to know

According to Penn Medicine, about 1 in 4 Americans experiences difficulty with sleep each year.

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