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A newly identified stem cell regulator enables lifelong sperm production
Illustration of different cell types that eventually give rise to sperm shows that blocking an early stage of cell development can prevent the formation of sperm

When the enzyme DOT1L is not functional, spermatogonial stem cells become exhausted, leading to a failure of sperm cell development. This crucial role for DOT1L places it in rarefied company as one of just a handful of known stem cell self-renewal factors, a Penn Vet team found. (Image: Courtesy of Jeremy Wang)

A newly identified stem cell regulator enables lifelong sperm production

Research led by Jeremy Wang of the School of Veterinary Medicine has discovered that the enzyme DOT1L, a stem cell renewal factor, is essential for mice to produce sperm throughout their adult lives.

Katherine Unger Baillie

University of Pennsylvania’s first NFT commemorates mRNA research
Lots of gold blobs, some larger and closer to the front of the image, some smaller and farther away, on a pinkish background.

A still image from the 3D animated video component of the non-fungible token, which will also include patent documents and a letter from Drew Weissman of Penn Medicine. (Image: Courtesy Penn Medicine and Christie’s)

University of Pennsylvania’s first NFT commemorates mRNA research

Proceeds from the July auction of the non-fungible token—a digital asset—will benefit ongoing research at Penn.

Penn Medicine, Brandon Lausch , Peter Winicov

Text messaging shows promise in reaching unvaccinated patients
Hands texting on a smartphone.

nocred

Text messaging shows promise in reaching unvaccinated patients

A Penn study finds that while automated texting did not get more patients to get their vaccinations against COVID-19, it reached roughly the same amount as manned phone calls.

From Penn Medicine News

Parental nicotine use and addiction risk for children
A put-out cigarette standing on its end, next to half of another crumpled cigarette. In the background are two whole cigarettes.
  • Q&A

    • Parental nicotine use and addiction risk for children

    In research done using rats, Penn Nursing’s Heath Schmidt and colleagues found that males that engaged in voluntary nicotine use had offspring more likely to do so, too. Some offspring also developed impaired memory and anxiety-like behavior.

    Michele W. Berger

    With summer’s return, a guide to avoiding drowning
    Young child wearing a life vest in the pool with two adults behind them.

    With summer’s return, a guide to avoiding drowning

    Zaffer Qasim of the Perelman School of Medicine analyzed the mortality data of drowning victims in the United States to prescribe treatment measures. Among other recommendations, he encourages everyone to get training in basic life support.

    From Penn Medicine News

    How Penn Family Medicine forms a foundation of LGBTQ+ primary care
    A masked doctor and patient speaking at a desk.

    How Penn Family Medicine forms a foundation of LGBTQ+ primary care

    The first primary care appointment for a patient who identify as LGBTQ is exactly like any appointment for any patient — clinicians are focused on treating them holistically and on listening to the concerns that brought them in for care.

    Alex Gardner

    A $365 million development will expand the life sciences hub at Pennovation Works
    Rendering depicting aerial view of new life sciences building on Pennovation Works campus

    A $365 million development will expand the life sciences hub at Pennovation Works

    Penn Senior Executive Vice President Craig Carnaroli speaks with Penn Today about the evolution of the research and manufacturing project, led by Longfellow Real Estate Developers, and its value for Penn and the region.

    Katherine Unger Baillie

    Promising results for chemo immunotherapy combination against pancreatic cancer
    A chemotherapy drip solution hanging by a sunlit window.

    Promising results for chemo immunotherapy combination against pancreatic cancer

    Penn Medicine researchers find a combination of chemotherapy with an immunotherapy meant to unleash the anticancer capacity of the immune system is effective against pancreatic cancer. The findings also include the identification of immune system biomarkers associated with better outcomes.

    Caren Begun