Targeted prenatal therapy addresses long-standing gap in health equity Image: iStock/Motortion Targeted prenatal therapy addresses long-standing gap in health equity Penn engineers have developed a successful delivery system of mRNA to placental cells to treat preeclampsia at its root.
New mRNA vaccine to fight 20 known subtypes of influenza Image: Bernard Chantal for Adobe Stock New mRNA vaccine to fight 20 known subtypes of influenza Heading into clinical trials, the new research from Penn Medicine may serve as a general preventative measure against future flu pandemics.
Behind the scenes in the lab and the future of mRNA research Behind the scenes in the lab and the future of mRNA research Developing new vaccines and novel mRNA delivery methods, coupled with the satisfaction of mentoring and selfless dedication to medicine, inspire the work of scientists at the Weissman Lab.
University of Pennsylvania’s first NFT commemorates mRNA research A still image from the 3D animated video component of the non-fungible token, which will also include patent documents and a letter from Drew Weissman of Penn Medicine. (Image: Courtesy Penn Medicine and Christie’s) University of Pennsylvania’s first NFT commemorates mRNA research Proceeds from the July auction of the non-fungible token—a digital asset—will benefit ongoing research at Penn.
From a pandemic, scientific insights poised to impact more than just COVID-19 Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today) From a pandemic, scientific insights poised to impact more than just COVID-19 Pivoting to study SARS-CoV-2, many scientists on campus have launched new research projects that address the challenges of the pandemic but also prepare us to confront future challenges.
Vaccine-like mRNA injection can be used to make CAR T cells in the body Vaccine-like mRNA injection can be used to make CAR T cells in the body An experimental immunotherapy can temporarily reprogram patients’ immune cells to attack heart fibroblast cells via only a single injection of mRNA.
From foundational discoveries to profound impact Today, Weissman and colleagues are working to develop a pan-coronavirus vaccine capable of protecting the population against SARS, MERS, SARS-CoV-2, and more. At BioNTech, Karikó is overseeing parallel but distinct research on a range of diseases in which patients receive mRNA encoding therapeutic proteins. (Image: Peggy Peterson) From foundational discoveries to profound impact How decades of mRNA research at Penn made powerful new COVID-19 vaccines possible—and opened a new vista for future discoveries.
Drew Weissman and Katalin Karikó receive 2021 Lasker Award mRNA scientists Drew Weissman, the Roberts Family Professor of Vaccine Research in Penn’s Perelman School of Medicine, and Katalin Karikó, an adjunct professor of neurosurgery at Penn and a senior vice president at BioNTech. (Image: Courtesy of Penn Medicine) Drew Weissman and Katalin Karikó receive 2021 Lasker Award Weissman and Karikó’s mRNA technology is recognized for enabling rapid development of highly effective COVID-19 vaccines
Penn engineers will develop on-demand, on-site mRNA manufacturing Bijels, or bicontinuous interfacially jammed emulsion gels, are structured emulsions of oil and water that are kept separated by a layer of nanoparticles. Penn Engineering researchers will develop a way of using them to manufacture mRNA-based therapeutics. (Image: Penn Engineering Today) Penn engineers will develop on-demand, on-site mRNA manufacturing With an NSF grant, Penn Engineering researchers are developing a new manufacturing technique that would be able to produce mRNA sequences in a way that removes the need for cryogenic temperatures.
mRNA COVID-19 vaccines induce T-cell responses in multiple sclerosis patients mRNA COVID-19 vaccines induce T-cell responses in multiple sclerosis patients Research from Penn Medicine shows mRNA COVID-19 vaccines are effective at inducing T-cell responses in multiple sclerosis patients who receive B cell-depleting Infusions even if their antibody responses are diminished.