With coral reefs under threat from climate change, pollutants, sedimentation, and other factors, Barott and colleagues hope to continue investigating how such challenges may influence coral reproduction and persistence. (Image: Courtesy of Kelsey Speer)
From corals to humans, a shared trigger for sperm to get in motion
Coral sperm require a specific pH to move, according to research from the School of Arts & Sciences, which identifies a signaling pathway that is shared by organisms including humans. The results inform how corals may fare with climate change.
Signals between the brain and stomach help animals decide when and how much to eat. A research collaboration involving Penn neuroscientists has uncovered a sensor for fullness in an area of the brain never before associated with satiation: the cerebellum. (Image: Courtesy of the Betley laboratory)
In the brain’s cerebellum, a new target for suppressing hunger
A research team led by J. Nicholas Betley in the School of Arts & Sciences has identified an entirely new way the brain signals fullness after eating. The findings offer a novel target for therapies that could dramatically curb overeating.
The multicenter study, led by researchers at the Perelman School of Medicine and Children’s Hospital of Philadelphia, showed improved and sustained production of a needed clotting factor and reduced bleeding events.
A new class of CAR T cells targets previously untargetable cancer drivers
Focusing on neuroblastoma, researchers from the Perelman School of Medicine and Children’s Hospital of Philadelphia have harnessed the immune system to destroy tumors.
With more kids eligible for vaccines, is the pandemic in a new phase?
With the FDA authorization last week, 28 million more children are eligible to be vaccinated against COVID-19. Experts from the School of Nursing and Perelman School of Medicine share their thoughts about what to expect in the weeks and months to come.
The opening of the Pavilion marks the completion of the University’s largest capital building project, and culmination of a planning and design process years in the making. (Image: Eric Sucar)
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Historic move ushers in new era of care
Over eight hours, 310 patients moved to the Pavilion, a 17-story, 1.5-million-square-foot addition to the Hospital of the University of Pennsylvania campus.
Wil Prall, a biology doctoral student, volunteered as part of Palm It Forward, an event organized by Palms Solutions to support the West Philadelphia community during the pandemic. (Image: Courtesy of Mecky Pohlschröder)
Supporting Philadelphia newcomers and longtime residents through Palms Solutions
Founded by a Penn alum, the West Philadelphia-based nonprofit connects members from area African and Caribbean immigrant communities with students through mentoring and tutoring alongside social and cultural exchanges.
A Penn Vet-led team was the first to sequence, study, and manipulate a naturally occurring mouse Cryptosporidium, a parasite responsible for life-threatening illness in people, as well as livestock, pets, and wildlife worldwide. (Image: Muthugapatti Kandasamy, Adam Sateriale, and Boris Striepen)
A hub for zoonotic disease research
The new Institute for Infectious and Zoonotic Diseases, launched by the School of Veterinary Medicine, leans on Penn’s strengths in immunology and infectious disease to prepare for emerging threats to animal and human health.
Pairing iron oxide nanoparticles with hydrogen peroxide results in a precisely targeted treatment for killing harmful oral bacteria, breaking down dental plaque, and even diagnosing harmful oral biofilms, according to a new study. (Image: Courtesy of the study authors)
An iron-oxide nanoparticle that is FDA-approved to treat anemia acts as an enzyme to activate hydrogen peroxide to suppress the growth of tooth-decay-causing biofilms in the human mouth, according to a study led by the School of Dental Medicine.
Novel gene therapy platform speeds search for ways to cure blindness
A newly developed single-cell RNA sequencing technique enables researchers to quickly identify an optimal vector for delivering therapeutic genetic material to treat vision disorders, and perhaps other genetic conditions.
A Penn Vet-led team was the first to sequence, study, and manipulate a naturally occurring mouse Cryptosporidium, a parasite responsible for life-threatening illness in people, as well as livestock, pets, and wildlife worldwide. (Image: Muthugapatti Kandasamy, Adam Sateriale, and Boris Striepen)
