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Bacteria boost antifungal drug resistance in severe childhood tooth decay
Koo.fungal shielding.2018

Bacteria boost antifungal drug resistance in severe childhood tooth decay

Some young children experience severe tooth decay that resist normal therapies. New research led by Dongyeop Kim and Hyun (Michel) Koo of the School of Dental Medicine shows how plaque’s protective matrix can shield fungal cells from the drugs intended to kill them.

Katherine Unger Baillie

Princess Chulabhorn of Thailand visits Penn, with scientific partnerships in mind
HRH Princess Chulabhorn with Penn group

Penn President Amy Gutmann and a delegation from the University welcomed HRH Princess Chulabhorn Mahidol of Thailand to discuss potential collaborations in science and health research and education.

Princess Chulabhorn of Thailand visits Penn, with scientific partnerships in mind

The princess met with President Amy Gutmann and leaders of Penn’s health schools on Thursday, April 5, to discuss future collaboration aimed at advancing health and science.

Katherine Unger Baillie

Unraveling how stem cells from gum tissue accelerate wound healing
Shi, Songtao.stem cells in the gums

To assist with wound healing, mesenchymal stem cells from the gum tissue secrete extracellular vesicles (labeled red) that contain the anti-inflammatory signaling molecule IL-1RA (labeled green). 

Unraveling how stem cells from gum tissue accelerate wound healing

Gum tissue stem cells heal twice as fast as skin, and researchers are determining their potential in accelerated wound healing research.

Katherine Unger Baillie

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges
Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis

Hajishengallis, an expert in the immune mechanisms behind the gum disease periodontitis, worked with an international team to show that the innate immune system--typically thought to lack immune memory--can in fact be trained to "remember" past threats.

By altering bone marrow, ‘training’ can prepare innate immune system for future challenges

George Hajishengallis of the School of Dental Medicine and an international team of colleagues have found that “training” the immune system causes changes in the precursors of immune cells in the bone marrow. These changes could facilitate a more robust response to future infections or even enable the immune system to regenerate faster after chemotherapy.

Katherine Unger Baillie

New Dental Material Resists Plaque and Kills Microbes, Penn Dental Team Finds

New Dental Material Resists Plaque and Kills Microbes, Penn Dental Team Finds

Dentists rely on composite materials to perform restorative procedures, such as filling cavities. Yet these materials, like tooth enamel, can be vulnerable to the growth of plaque, the sticky biofilm that leads to tooth decay.

Katherine Unger Baillie

Improving oral cancer diagnosis on many fronts

Improving oral cancer diagnosis on many fronts

A comprehensive dental visit includes more than a cleaning and X-rays; well-trained dentists know they must also take a thorough look inside the oral cavity to spot any potentially unusual lesions that could signal oral cancer.

Katherine Unger Baillie

New Coursera Offering From Penn Explores Ties Between Medicine and Dentistry

New Coursera Offering From Penn Explores Ties Between Medicine and Dentistry

By Erica AndersenDentists and physicians practice health care from different perspectives, however, the oral and general health of their patients are of primary importance to both types of providers. A new online course taught by University of Pennsylvania faculty seeks to highlight the inextricable connections between the two professions.

Katherine Unger Baillie