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Penn Muscle Institute Biologists Receive $9 Million to Research Cellular Motors
Researchers in the Pennsylvania Muscle Institute (PMI), based at the Perelman School of Medicine at the University of Pennsylvania have received $9 million over the next five years from the National Institute of General Medical Sciences to investigate the biology of cellular motors.
Penn Medicine: Zebrafish Model of a Learning and Memory Disorder Shows Better Way to Target Treatment
Using a zebrafish model of a human genetic disease called neurofibromatosis (NF1), a team from the Perelman School of Medicine at the University of Pennsylvania has found that the learning and memory components of the disorder are distinct features that will likely need different treatment approaches.
Penn Researcher and CVS Health Physician Urge New Payment Model for Costly Gene Therapy Treatments
Hoping to encourage sufficient investments by pharmaceutical companies in expensive gene therapies, which often consist of a single treatment, a Penn researcher and the chief medical officer of CVS Health outline an alternative payment model in this month’s issue of Nature Biotechnology.
Penn Team Finds Ovarian Cancer Oncogene in 'Junk DNA'
Over the years researchers have made tremendous strides in the understanding and treatment of cancer by searching genomes for links between genetic alterations and disease.
Penn Medicine Study: Attacking a Rare Disease at its Source With Gene Therapy
Treating the rare disease MPS I is a challenge. MPS I, caused by the deficiency of a key enzyme called IDUA, eventually leads to the abnormal accumulation of certain molecules and cell death.
Drug for Rare Blood Disorder Developed at Penn Receives Orphan Drug Status from European Union
A Penn Medicine-developed drug has received orphan status in Europe this week for the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare, life-threatening disease that causes anemia due to destruction of red blood cells and thrombosis.
Penn Physiologist Given NIH Javits Neuroscience Investigator Award for Research on Neurodegeneration
Erika Holzbaur, PhD, a professor of Physiology in the Perelman School of Medicine at the University of Pennsylvania, has received the Javits Neuroscience Investigator Award from the National Institutes of Health.
Penn Researchers Receive $7.3 Million Grant Renewal from NCI to Study Esophageal Cancer
Researchers at the Perelman School of Medicine at the University of Pennsylvania will receive $7.3 million over the next five years from the National Cancer Institute (NCI) to find new ways to treat esophageal cancer.
Atomic Structure of Key Muscle Component Revealed in Penn Study
Actin is the most abundant protein in the body, and when you look more closely at its fundamental role in life, it’s easy to see why. It is the basis of most movement in the body, and all cells and components within them have the capacity to move: muscle contracting, heart beating, blood clotting, and nerve cells communicating, among many other functions.
Penn Study: Metabolic Enzyme Stops Progression of Most Common Type of Kidney Cancer
In an analysis of small molecules called metabolites used by the body to make fuel in normal and cancerous cells in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth.