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Karen Kreeger
Penn Team Finds that Most-Used Diabetes Drug Works in Different Way than Previously Thought
PHILADELPHIA - A team, led by senior author Morris J.
Karen Kreeger ・
Penn Team Developing New Class of Malaria Drugs Using Essential Calcium Enzyme
PHILADELPHIA — Calpain, a calcium-regulated enzyme, is essential to a host of cellular processes, but can cause severe problems in its overactivated state. It has been implicated as a factor in muscular dystrophy, AIDS, Alzheimer's disease, multiple sclerosis, and cancer. As such, finding and exploiting calpain inhibitors is an important area of research.
Karen Kreeger ・
Penn Team Mimicking a Natural Defense Against Malaria to Develop New Treatments
PHILADELPHIA — One of the world's most devastating diseases is malaria, responsible for at least a million deaths annually, despite global efforts to combat it. Researchers from the Perelman School of Medicine at the University of Pennsylvania, working with collaborators from Drexel University, The Children's Hospital of Philadelphia, and Johns Hop
Karen Kreeger ・
Protein Kinase Akt Identified as Arbiter of Cancer Stem Cell Fate, According to Penn Study
PHILADELPHIA — The protein kinase Akt is a key regulator of cell growth, proliferation, metabolism, survival, and death.
Karen Kreeger ・
Five Penn Professors Named AAAS Fellows
PHILADELPHIA – Five faculty members at the University of Pennsylvania have been named Fellows of the American Association for the Advancement of Science. Two are from Penn’s Perelman School of Medicine, two are from its School of Arts and Sciences
Karen Kreeger, Evan Lerner ・
Penn Scientist Named First Director of New Center for Orphan Disease Research and Therapy
PHILADELPHIA — H. Lee Sweeney, Ph.D., the William Maul Measey Professor at the Perelman School of Medicine, University of Pennsylvania, has been named the inaugural director of Penn’s Center for Orphan Disease Research and Therapy.
Karen Kreeger ・
Penn-Temple Team Discovers What Keeps a Cell's Energy Source Going
PHILADELPHIA — Most healthy cells rely on a complicated process to produce the fuel ATP. Knowing how ATP is produced by the cell’s energy storehouse – the mitochondria -- is important for understanding a cell’s normal state, as well as what happens when things go wrong, for example in cancer, cardiovascular disease, neurodegeneration, and many rare disorders of the mitochondria.
Karen Kreeger ・
Penn Medicine Research: Pathway Identified in Human Lymphoma Points Way to New Blood Cancer Treatments
PHILADELPHIA — A pathway called the “Unfolded Protein Response,” or UPR, a cell’s way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.
Karen Kreeger ・
Penn Study Decodes Molecular Mechanisms Underlying Stem Cell Reprogramming
PHILADELPHIA — Fifty years ago, UK researcher John Gurdon demonstrated that genetic material from non-reproductive cells could be reprogrammed into an embryonic state when transferred into an egg.
Karen Kreeger ・
Penn Medicine: Parkinson's Disease Protein Causes Disease Spread and Neuron Death in Healthy Animals
PHILADELPHIA — Understanding how any disease progresses is one of the first and most important steps towards finding treatments to stop it. This has been the case for such brain-degenerating conditions as Alzheimer's disease.
Karen Kreeger ・