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Penn Study: Codependence of Cell Nucleus Proteins Key to Understanding Fatty Liver Disease
A new appreciation for the interplay between two cell nucleus proteins that lead both intertwined and separate lives is helping researchers better understand fatty liver disease, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.
Penn Medicine: Hybrid Immune Cells in Early-Stage Lung Cancer Spur Anti-Tumor T Cells to Action
The microenvironment of tumors is a mix of cell types, mostly comprised of inflammatory cells. White blood cells, recruited from the blood and bone marrow, represent a significant portion of these inflammatory cells and influence nearly all steps of tumor progression.
Penn Medicine: New Therapy Treats Autoimmune Disease Without Harming Normal Immunity
In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.
Penn Study: New Antiviral Drugs Could Come From DNA ‘Scrunching’
Evidence of DNA “scrunching” may one day lead to a new class of drugs against viruses, according to a research team from the Perelman School of Medicine at the University of Pennsylvania, the Georgia Institute of Technology, and Columbia University. The team is led by Stephen C.
Penn Study Describes a Better Animal Model to Improve HIV Vaccine Development
Vaccines are usually medicine’s best defense against the world’s deadliest microbes. However, HIV is so mutable that it has so far effectively evaded both the human immune system and scientists’ attempts to make an effective vaccine to protect against it.
Two Penn Professors Elected to the American Academy of Arts and Sciences
Two professors from the University of Pennsylvania have been elected to the American Academy of Arts and Sciences.
Penn Medicine: Proof-of-Concept Animal Study Shows that Flexible, Dissolvable Silicon Electronic Device Holds Promise for Brain Monitoring
An implantable brain device that literally melts away at a pre-determined rate minimizes injury to tissue normally associated with standard electrode implantation, according to research led by a team from the Perelman School of Medicine at the University of Pennsylvania.
Quieting Cells' Low-Oxygen Alarm Stops Flare-ups in Rare Bone Disorder, Penn Animal Study Finds
The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which limits motion, breathing, and swallowing, among a host of progressive symptoms.
Penn Institute for Biomedical Informatics and colleagues Identify "Roadmap" of Disease Mechanisms to Identify Candidate Drug Targets
The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets, according to a collaboration between the Perelman School of Medicine at the University of Pennsyl