Perelman School of Medicine

Positive results in first-in-U.S. trial of CRISPR-edited immune cells

Genetically editing a cancer patient’s immune cells using CRISPR/Cas9 technology, then infusing those cells back into the patient appears safe and feasible based on early data from the first-ever clinical trial to test the approach in humans in the United States.

To monitor cancer therapy, researchers tag CAR T cells with imaging markers

With CAR T cell therapy, a patient’s own immune cells are genetically modified and inserted back into the body to find and kill cancer. Now scientists have now discovered a new way to track CAR T cells in the body.

Floor view of a person stepping onto a scale on a bath mat

Bariatric surgery is safe for teens with morbid obesity

A new Penn Medicine study shows the risks of complications and readmissions may be lower than the risks associated with lifelong obesity.

MRI scan of brain and hand with a red marker pointing at a mark on the scan.

Blood test can predict prognosis in deadly brain cancer

A Penn study points to clinical utility of liquid biopsy in glioblastoma, allowing doctors the ability to measure the progression of the cancer based on the amount of cell-free DNA in the bloodstream

Basser Center takes aim at BRCA

Twenty-five years after the discovery of genetic mutations that dramatically increase cancer risk, the Penn Medicine’s Basser Center for BRCA is building scientific knowledge alongside public awareness about BRCA-related cancers.

Lifelong no longer: New research on TB infection rarely leads to active disease

A Penn-led study suggested majority will not develop disease even if a test shows positive results, citing that the infecting organism, Mycobacterium tuberculosis, is likely dead, wiped out naturally by people’s immune systems.

Person in a lab coat sitting on a wooden bench outside.

Physicians, social responsibility, and sexual assault survivors

Penn Medicine’s Florencia Greer Polite wants doctors to take a more proactive approach to conversations with their patients about consent and sexual abuse.

Philadelphia city street, abandoned factory in background, housing behind sidewalk fence.

A focus on environmental inequities

A Penn symposium will confront issues of inequitable access to a clean and safe environment and the unequal burden borne by vulnerable communities, particularly low-income and underrepresented minority populations, when it comes to environmental threats.

Cultivando Juntos team members standing in nursing building

Cultivando Juntos takes shape in Kennett Square

As part of their President’s Engagement Prize project, José Maciel and Antonio Renteria are reframing the concept of healthy living for mushroom farmworkers.

shape of a human head made of outlines of wine glasses, drink glasses and beer bottles.

Consuming alcohol leads to epigenetic changes in brain memory centers

What drives the biology behind alcohol cravings has remained largely unknown. A new Penn study shows how a byproduct of the alcohol breakdown produced mostly in the liver travels to the brain’s learning system and impacts behavior around environmental cues to drink.

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