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First Microscopic Video of Blood Clot Contraction Reveals How Platelets Naturally Form Unobtrusive Clots

First Microscopic Video of Blood Clot Contraction Reveals How Platelets Naturally Form Unobtrusive Clots

The first view of the physical mechanism of how a blood clot contracts at the level of individual platelets is giving researchers from the Perelman School of Medicine at the University of Pennsylvania a new look at a natural process that is part of blood clotting. A team led by John W.

Karen Kreeger

Paving a New Path to Parenthood: Penn Medicine Launches First Clinical Trial for Uterine Transplant in the Northeast

Paving a New Path to Parenthood: Penn Medicine Launches First Clinical Trial for Uterine Transplant in the Northeast

Penn Medicine will conduct the Northeast’s first clinical trial of uterine transplants, to provide women with Uterine Factor Infertility (UFI) - an irreversible form of female infertility that affects as many as 5 percent of women worldwide and 50,000 women in the United States - with a new path to parenthood.

Abbey Anderson

Penn Medicine: Blood Flow in the Developing Heart Guides Maturation of Heart Valves

Penn Medicine: Blood Flow in the Developing Heart Guides Maturation of Heart Valves

Congenital heart valve defects appear in 2 percent of all live births, making them the most common type of birth defect. While some of these defects have been linked to specific genetic mutations, the majority have no clearly definable genetic cause, suggesting that epigenetic factors – changes in gene expression versus an alteration in the genetic code -- play an important role.

Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers

Penn Study Links Mutations in Notch Gene to Role in B Cell Cancers

Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such as mantle cell lymphoma. However, the role of Notch in these cancers has been uncertain.

Karen Kreeger

Moonshot Grant Will Help Researchers See Two of Cancer’s Key Food Sources at Once

Moonshot Grant Will Help Researchers See Two of Cancer’s Key Food Sources at Once

Imagine trying to take a picture of a runner, but only being able to see her feet. If you could see her whole body, you’d get the full picture of how she uses both legs to put one foot in front of the other to reach top speed.

John Infanti