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Perelman School of Medicine
Penn: Stressed Dads Affect Offspring Brain Development Through Sperm MicroRNA
More and more, scientists have realized that DNA is not the only way that a parent can pass on traits to their offspring. Events experienced by a parent over a lifetime can also have an impact.
Penn Researchers: New Neuroimaging Method Better Identifies Epileptic Lesions
Epilepsy affects more than 65 million people worldwide. One-third of these patients have seizures that are not controlled by medications. In addition, one-third have brain lesions, the hallmark of the disease, which cannot be located by conventional imaging methods.
Off-Kilter: Penn Study Identifies Differences in Treatment Effect on Out-of-Balance Microbiome in Crohn's Disease
Different treatments for Crohn's disease in children affects their gut microbes in distinct ways, which has implications for future development of microbial-targeted therapies for these patients, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania
Turncoat Protein Regulates Sensitivity of Breast Cancer Cells to Drug, Providing New Target for Preventing Relapses, Finds Penn Study
A surprising, paradoxical relationship between a tumor suppressor molecule and an oncogene may be the key to explaining and working around how breast cancer tumor cells become desensitized to a common cancer drug, found researchers at the Perelman School of Medicine at the University of Pennsylvania
Penn Medicine Researchers Discover Hidden Brain Pathways Crucial to Communication
Being able to understand speech is essential to our evolution as humans. Hearing lets us perceive the same word even when spoken at different speeds or pitches, and also gives us extra sensitivity to unexpected sounds.
Penn Team Maps First Comprehensive Profile of Non-Protein-Coding RNAs to Provide Clinicians with New Way to Diagnose Array of Cancers
Growing insights about a significant, yet poorly understood, part of the genome – the “dark matter of DNA” -- have fundamentally changed the way scientists approach the study of diseases. The human genome contains about 20,000 protein-coding genes – less than 2 percent of the total – but 70 percent of the genome is made into non-coding RNA.
Penn Study Stops Vision Loss in Late-stage Canine X-linked Retinitis Pigmentosa
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Cancer Doesn't Sleep: The Myc Oncogene Disrupts Circadian Rhythm and Metabolism in Cancer Cells, Finds New Penn Study
Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania. Postdoctoral fellow Brian Altman, PhD, and doctoral student Annie Hsieh, MD, both from the lab of senior author Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, study body clock proteins associated with cancer cells.
Multiple Myeloma Patients More Vulnerable to 'Financial Toxicity' Due to Expensive, Longer Courses of Treatments, Penn Study Finds
Even patients with health insurance who have multiple myeloma may be vulnerable to “financial toxicity” – including those who make over $100,000 a year – because of the higher use of novel therapeutics and extended duration of myeloma treatment, researchers from Penn’s Abramson Cancer Center report in this week’s
Penn Team Pinpoints Immune Changes in Blood of Melanoma Patients on PD-1 Drugs That Put Potential Biomarker within Reach
A simple blood test can detect early markers of “reinvigorated” T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
In the News
Fox 29 (Philadelphia)
Cannabis reclassification could be game-changer for U.S. drug policy
Michael Cirigliano of the Perelman School of Medicine says that marijuana deserves to be removed from the same category as LSD, heroin, and fentanyl.
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The Washington Post
Americans are sleeping more than ever. See how you compare
Mathias Basner of the Perelman School of Medicine says that work and traveling are the major sleep killers, with the majority of traveling being commuting to and from work.
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Newsweek
Man does DNA test, not prepared for what comes back ‘unusually high’
César de la Fuente of the School of Engineering and Applied Science and Perelman School of Medicine says that Neanderthal DNA provides insights into human evolution, population dynamics, and genetic adaptations, including correlations with traits such as immunity and susceptibility to diseases.
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Philadelphia Inquirer
Cardiac arrest recoveries are great stories, but they’re rare. We can fix that
In an opinion essay, Raina Merchant of the Perelman School of Medicine says that low survival rates for cardiac arrest can be improved by increasing rates of CPR.
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Women’s Health
How does fat leave the body? Experts explain the weight loss process
Colleen Tewksbury of the School of Nursing and Perelman School of Medicine says that waist circumference is a more accessible and potentially more helpful measure for fat loss than stepping on a scale.
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