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Penn Medicine: New Mouse Model Points to Drug Target Potentially Useful for Increasing Social Interaction in Autism

Penn Medicine: New Mouse Model Points to Drug Target Potentially Useful for Increasing Social Interaction in Autism

A study of a new mouse model identifies a drug target that has the potential to increase social interaction in individuals with some forms of autism spectrum disorder (ASD), according to researchers in the Perelman School of Medicine at the University of Pennsylvania.

Karen Kreeger

Penn: Blinding Disease in Canines and Humans Shares Causative Gene, Pathology

Penn: Blinding Disease in Canines and Humans Shares Causative Gene, Pathology

Ciliopathies are diseases that affect the cilia, sensory organelles that most mammalian cells possess and which play a critical role in many biological functions. One such disease is Senior Løken Syndrome, a rare condition that can involve both a severe kidney disease and the blinding disease Leber congenital amaurosis, or LCA.

Katherine Unger Baillie

Penn Team Identifies Strategy to Reverse the Disease Dyskeratosis Congenita

Penn Team Identifies Strategy to Reverse the Disease Dyskeratosis Congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure. Typically diagnosed in childhood, the disorder causes stem cells to fail, leading to significant problems including bone marrow failure, lung fibrosis, dyskeratosis of the skin and intestinal atrophy and inflammation.

Katherine Unger Baillie

Penn Study: Codependence of Cell Nucleus Proteins Key to Understanding Fatty Liver Disease

Penn Study: Codependence of Cell Nucleus Proteins Key to Understanding Fatty Liver Disease

A new appreciation for the interplay between two cell nucleus proteins that lead both intertwined and separate lives is helping researchers better understand fatty liver disease, according to a new study by researchers at the Perelman School of Medicine at the University of Pennsylvania.

Karen Kreeger

Penn Team Uses Nanoparticles to Break Up Plaque and Prevent Cavities

Penn Team Uses Nanoparticles to Break Up Plaque and Prevent Cavities

The bacteria that live in dental plaque and contribute to tooth decay often resist traditional antimicrobial treatment, as they can “hide” within a sticky biofilm matrix, a glue-like polymer scaffold.

Katherine Unger Baillie