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Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles
3D illustration showing cross-section of the lipid nanoparticle carrying mRNA of the virus entering a human cell.

Lipid nanoparticles present one of the most advanced drug delivery platforms to shuttle promising therapeutics such as mRNA but are limited by the time it takes to synthesize cationic lipids, a key component. Now, Michael Mitchell and his team at the School of Engineering and Applied Science have developed a faster way to make cationic lipids that are also more versatile, able to carry different kinds of treatments to target specific organs.

(Image: iStock / Dr_Microbe)

Penn pioneers a ‘one-pot platform’ to promptly produce mRNA delivery particles

New lipid platform enables rapid synthesis of molecules that can shuttle therapeutics for a range of diseases with a high degree of organ specificity.
Better survival rates from hospital-based donor care for lung transplants
lungs suspended in a block of ice.

Image: iStock/AlexLMX

Better survival rates from hospital-based donor care for lung transplants

A new study by Penn researchers has examined, for the first time, the differences in lung transplant graft outcomes from organs recovered from the two types of deceased organ donor care facilities operating in the United States.

From Penn Medicine News

The power of protons
Two nurses guiding a prone patient into a proton imaging machine.

(On homepage) Until recently, proton therapy has occupied a small niche within the field of radiation oncology. Penn Medicine has played a leading role in championing proton therapy and moving the field forward.

(Image: Scott Nibauer)

The power of protons

Penn Medicine has treated more than 10,000 cancer patients at three proton therapy centers across the region, including the largest and busiest center in the world—while also leading the way in research to expand the healing potential of these positive particles.

Kirsten Weir for Penn Medicine Magazine

How to learn about a world-class double bass? Give it a CT
Philadelphia Orchestra bassist Duane Rosengard; Peter Noël, director of CT Research at the Perelman School of Medicine; luthier Zachary S. Martin; Leening Liu, a Ph.D. student in Noël’s Laboratory of Advanced Computed Tomography Imaging; and Mark Kindig.

Image: Courtesy of Penn Medicine News

How to learn about a world-class double bass? Give it a CT

Radiology experts at Penn Medicine applied imaging technology to centuries-old instruments to better understand how to care for masterworks built between the 17th and 19th centuries, and provide insights into building new ones.

From Penn Medicine News

New approach accurately identifies medications most toxic to the liver
Internal view of a diseased liver.

Image: iStock/Mohammed Haneefa Nizamudeen

New approach accurately identifies medications most toxic to the liver

A Penn Medicine-led study developed a novel approach to using health care data to measure rates of liver injury, as the current method of counting cases is not providing an accurate picture.

Frank Otto

Gender-affirming care at Penn Medicine: A future ‘not in the shadows’
A group of people posing and smiling in front of a polka dot backdrop.

Mattie Chaya Kimberly “Kimi” Klauser (in hat second from right) with her bandmates.

(Image: Courtesy of Penn Medicine News)

Gender-affirming care at Penn Medicine: A future ‘not in the shadows’

The Penn Medicine Program for LGBTQ+ Health and gender-affirming care at Penn Medicine has helped Mattie Chaya Kimberly “Kimi” Klauser and others get the right care in an open, safe, and nurturing environment.
Connecting the West Philadelphia community to careers 
west philly skills initiative med worker

nocred

Connecting the West Philadelphia community to careers 

The West Philadelphia Skills Initiative is a workforce development partnership between the University City District, Penn Medicine, and the University committed to develop career opportunities for local residents.

From Penn Medicine Service in Action

Hurricane changed ‘rules of the game’ in monkey society
A group of rhesus macaques sits amidst the bare, leafless trees of their hurricane-impacted habitat.

For more than 17 years, PIK Professor Michael Platt and his collaborators have followed a free-ranging colony of rhesus macaques in the Puerto Rican Island of Cayo Santiago who, in 2017, experienced the devastation of Hurricane Maria. The team showed that the macaques who invested in relationships had higher survival rates, findings that can provide insights into human social behavior and health in the face of environmental change.

(Image: Courtesy of Lauren J. Brent) 

Hurricane changed ‘rules of the game’ in monkey society

PIK Professor Michael Platt and collaborators from the University of Exeter find Hurricane Maria transformed a monkey society by changing the pros and cons of their interpersonal relations.