Perelman School of Medicine

Penn Study Cautions Use of Drugs to Block 'Niacin Flush' in Heart Patients

Niacin, or vitamin B3, is the one approved drug that elevates "good" cholesterol (high density lipoprotein, HDL) while depressing "bad" cholesterol (low density lipoprotein , LDL), and has thereby attracted much attention from patients and physicians. Niacin keeps fat from breaking down, and so obstructs the availability of LDL building blocks.

Karen Kreeger

Penn Medicine Researchers Find that Molecular Pair Controls Time-Keeping and Fat Metabolism

The 24-hour internal clock controls many aspects of human behavior and physiology, including sleep, blood pressure, and metabolism. Disruption in circadian rhythms leads to increased incidence of many diseases, including metabolic disease and cancer. Each cell of the body has its own internal timing mechanism, which is controlled by proteins that keep one another in check.

Karen Kreeger

Duality of Longevity Drug Explained by Penn Medicine Researchers

A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend on inhibiting two protein complexes, mTORC1 and mTORC2, respectively.

Karen Kreeger

Penn Researchers Call for a Re-Examination of Transplant Waitlist Prioritization

Patients with end-stage liver disease complicated by the most common type of liver cancer — hepatocellular carcinoma (HCC) — are less likely to die or become too sick for a transplant while waiting for a new liver than those with other complications of end-stage liver disease, according to new research from the Perelman School of Medicine at the Univ

Katie Delach



In the News


The New York Times

How Kennedy could make it harder for you and your family to get vaccinated

In a co-written opinion essay, PIK Professor Ezekiel Emanuel explains how Robert F. Kennedy Jr. and his allies in the Trump administration could discourage the use and research of vaccines.

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The New York Times

Elon Musk asked people to upload their health data. X users obliged

Matthew McCoy of the Perelman School of Medicine recommends not contributing private health data to the X chatbot Grok as an individual user.

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Philadelphia Inquirer

Penn is giving out free gun safes to help Philadelphians secure their firearms

Penn Medicine is giving out gun safes and locks to help people keep their firearms safe from children in the home, with remarks from Sunny V. Jackson and Neda Khan.

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The Washington Post

Is it anxiety or something else? What women should know

Lily Brown of the Perelman School of Medicine says that rates of anxiety disorders skyrocket around the time of first menstruation in puberty.

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Philadelphia Inquirer

Penn is offering free Narcan through vending machine on campus

A vending machine on Penn’s campus will offer free Narcan and other wellness and health products, with remarks from Jackie Recktenwald and Benoit Dubé of Wellness at Penn.

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