Perelman School of Medicine

Two reports by addiction researchers at the University of Pennsylvania School of Medicine and the National Institute on Drug Abuse show a drastic shift in prescribing patterns impacting the magnitude of opioid substance abuse in America.

Each year, more than 100,000 patients in the U.S. undergo implantation of a new implantable cardioverter defibrillator (ICD) for heart rhythm abnormalities. This number constitutes a 20-fold increase over the last 15 years. Current medical guidelines advocate discussion of end of life care of these medical devices, including deactivation, but many patients may not understand their options.

Researchers at the University of Pennsylvania School of Medicine may have found a way to turn an adaptive cellular response into a liability for cancer cells. When normal cells are starved for food, they chew up existing proteins and membranes to stay alive.

Current research supports the notion that lifestyle choices influence cardiovascular health, but to what extent specific emotions play is undefined. Now, new research from the University of Pennsylvania School of Medicine has revealed the role that guilt may play as a motivational tool for cardiovascular patients.

Just released data from a clinical trial shows continued promise for a new minimally invasive treatment option for patients with severe aortic stenosis.  New research presented at the 2011 American College of Cardiology (ACC) Scientific Sessions from the first arm, Cohort A, of the Placement of Aortic Transcatheter Valves (PARTNER) Trial shows that transcatheter aortic valve implantation

Psoriasis is a common inflammatory skin disease, and if severe, has been demonstrated to be a risk factor for cardiovascular (CV) disease. However, the degree to which psoriasis is associated with major adverse cardiac events (MACE), such as heart attack, stroke, and cardiovascular death has not been defined.

Researchers at the University of Pennsylvania School of Medicine have determined that a well-known chemical process called acetylation has a previously unrecognized association with one of the biological processes associated with Alzheimer’s disease and related disorders.

By combining sophisticated mathematical techniques more commonly used by spies instead of scientists with the power and versatility of functional magnetic resonance imaging (fMRI), a Penn neurologist has developed a new approach for studying the inner workings of the brain.

A new analysis by researchers at the University of Pennsylvania School of Medicine of recent cardiology clinical practice guidelines has found that more than half of the experts involved in the development of these guidelines reported a conflict of interest (COI).

Researchers at the University of Pennsylvania’s Abramson Cancer Center have discovered a novel way of treating pancreatic cancer by activating the immune system to destroy the cancer’s scaffolding. The strategy was tested in a small cohort of patients with advanced pancreatic cancer, several of whose tumors shrank substantially.