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Protein controlled by both light and temperature can inform cell signal pathways
Microscopic view of cells illuminated by light.

Protein controlled by both light and temperature can inform cell signal pathways

Penn Engineering researchers have described a new type of optogenetic protein that can be controlled not only by light, but also by temperature, allowing for a higher degree of control in the manipulation of cellular pathways.

From Penn Engineering Today

Researchers find new potential targets for skin-cancer treatment
Microscopic view of skin tissue cells.

Researchers find new potential targets for skin-cancer treatment

Making up for the genetic mutations of MLL4 in skin cells, one of the most commonly mutated genes across all of human cancers, may keep epithelial cancer from beginning and progressing

Alex Gardner

Catching up with omicron
Microscopic view of numerous particles of SARS-CoV-2 labeled blue emerging from an infected cell.

Particles of SARS-CoV-2, the virus that causes COVID-19, emerged from a cell infected in a lab. Researchers and clinicians at Penn and around the world have turned their attention to omicron, a recently emerged variant that is sweeping through the population. (Image: National Institute of Allergy and Infectious Diseases)

Catching up with omicron

The Perelman School of Medicine’s Frederic Bushman and Susan Weiss share what they and other scientists are learning about the new, dominant variant of SARS-CoV-2.

Katherine Unger Baillie

A structural blueprint of nanoparticles to target acute lung inflammation
X-ray of lungs illuminated in red.

A structural blueprint of nanoparticles to target acute lung inflammation

Targeting neutrophils, a type of white blood cell that, when overactive, contributes to acute lung inflammation, is a potential new route to diagnose and treat acute respiratory distress syndrome.

From Penn Medicine News

From foundational discoveries to profound impact
weissman and kariko in the lab Today, Weissman and colleagues are working to develop a pan-coronavirus vaccine capable of protecting the population against SARS, MERS, SARS-CoV-2, and more. At BioNTech, Karikó is overseeing parallel but distinct research on a range of diseases in which patients receive mRNA encoding therapeutic proteins. (Image: Peggy Peterson)

From foundational discoveries to profound impact

How decades of mRNA research at Penn made powerful new COVID-19 vaccines possible—and opened a new vista for future discoveries.

Ashley Rabinovitch

The COVID landscape after a year with vaccines
Vials labeled "SARS-CoV-2 COVID-19 Vaccine" lit up with neon light on a machine filling them.

nocred

The COVID landscape after a year with vaccines

In a conversation hosted by LDI, experts from Penn, the Black Doctors COVID-19 Consortium, and the Coalition for Epidemic Preparedness Innovations discussed the vaccine rollout, boosters, misinformation, and more.

Michele W. Berger

In Peru and the U.S., considering the factors that drive public health
Michael Levy

Michael Z. Levy, whose own research uses interdisciplinary methods to shed light on epidemiology and public health, taught the course with colleague César Ugarte-Gil and featured a bevy of guest experts. (Image: Peggy Peterson)

In Peru and the U.S., considering the factors that drive public health

By comparing and contrasting the two nations’ approaches to controlling infectious diseases, students in Parallel Plagues deepened their appreciation of how these diseases emerge, cause harm, and might be effectively controlled.

Katherine Unger Baillie