Perelman School of Medicine

DNA helix with a piece being removed by a surgeon’s glove with scissors.

New gene-editing technique can ‘turn on’ enzymes that cause DNA base mutations

The novel Penn method of splitting specific mutator enzymes and then triggering them to reconstitute has been patented, and allows for new possibilities in biologic and therapeutic research, including cancer.

A ‘dented’ internal clock informs shift workers’ weight gain and diabetes

Weight gain and high blood sugar caused by a damaged internal clock was corrected by Penn researchers, who changed the length of the day in tests.

Entering a new phase in cell therapy for glioblastoma

Donald M. O’Rourke, director of the Glioblastoma Translational Center of Excellence at Penn Medicine, and others are exploring cellular immunotherapies as a potential better option for deadly brain cancer glioblastoma multiforme.

Four nurses in gowns and masks standing smiling in a row.

Ethnic and racial diversity in surgical faculty associated with medical student diversity

A new study confirms there is little progress made in the last decade to expand racial and ethnic diversity in surgical faculty, despite evidence that more diverse faculty leads to greater racial, ethnic, and gender diversity in the medical student population.

Illustration representing T cells attacking cancer cells

A new class of CAR T cells targets previously untargetable cancer drivers

Focusing on neuroblastoma, researchers from the Perelman School of Medicine and Children’s Hospital of Philadelphia have harnessed the immune system to destroy tumors.

Medical professional looking closely with a smartphone lens at pigment on a person’s arm.

Drugs designed for prostate cancer may treat melanoma in men

A new Penn study finds that testosterone contributes to sex differences in melanoma via the activation of the zinc transporter ZIP9.

Child wearing mask in school writes at a desk

With more kids eligible for vaccines, is the pandemic in a new phase?

With the FDA authorization last week, 28 million more children are eligible to be vaccinated against COVID-19. Experts from the School of Nursing and Perelman School of Medicine share their thoughts about what to expect in the weeks and months to come.

Historic move ushers in new era of care

Over eight hours, 310 patients moved to the Pavilion, a 17-story, 1.5-million-square-foot addition to the Hospital of the University of Pennsylvania campus.

Red blood cells play much larger role in immune system via DNA-binding

Penn Medicine researchers have uncovered mechanism of how red blood cells detect and bind DNA, opening a new area of research for treatment of inflammatory diseases.

Empty hospital bed and wheelchair in a health care facility with curtains drawn.

Yelp star ratings may reveal county-level death rate disparities

A one-star disparity on health care facility Yelp reviews could indicate a 60-death-per-year difference between some United States counties where those facilities are located.

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