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Penn Team Identifies Strategy to Reverse the Disease Dyskeratosis Congenita

Penn Team Identifies Strategy to Reverse the Disease Dyskeratosis Congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure. Typically diagnosed in childhood, the disorder causes stem cells to fail, leading to significant problems including bone marrow failure, lung fibrosis, dyskeratosis of the skin and intestinal atrophy and inflammation.

Katherine Unger Baillie

Penn Team Finds Mitochondrial Stress Induces Cancer-related Metabolic Shifts

Penn Team Finds Mitochondrial Stress Induces Cancer-related Metabolic Shifts

Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts that enable a tumor’s rapid growth.

Katherine Unger Baillie

Penn-led Study Resolves Long-disputed Theory About Stem Cell Populations

Penn-led Study Resolves Long-disputed Theory About Stem Cell Populations

Adult stem cells represent a sort of blank clay from which a myriad of different cell and tissue types are molded and as such are of critical importance to health, ageing and disease.  In tissues that turn over rapidly, such as the intestines, the self-renewing nature of stem cells and their susceptibility to cancer-causing mutations has led researchers to postulate that

Katherine Unger Baillie

Penn Vet Research Suggests a Way to Identify Animals at Risk of Blood Clots

Penn Vet Research Suggests a Way to Identify Animals at Risk of Blood Clots

Patients who are critically ill, be they dog, cat or human, have a tendency toward blood clotting disorders. When the formation of a clot takes too long, it puts them at risk of uncontrolled bleeding. But the other extreme is also dangerous; if blood clots too readily and a clot travels to the lungs, brain or heart, it can lead to organ failure or even death.

Katherine Unger Baillie

Fossil Dog Represents a New Species, Penn Paleontology Grad Student Finds

Fossil Dog Represents a New Species, Penn Paleontology Grad Student Finds

A doctoral student at the University of Pennsylvania has identified a new species of fossil dog. The specimen, found in Maryland, would have roamed the coast of eastern North America approximately 12 million years ago, at a time when massive sharks like megalodon swam in the oceans.

Katherine Unger Baillie

Three Penn Students Named HHMI Medical Research Fellows

Three Penn Students Named HHMI Medical Research Fellows

Three graduate students from the University of Pennsylvania have been selected as Medical Research Fellows by the Howard Hughes Medical Institute.

Katherine Unger Baillie , Stephen Graff