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Penn Researchers Identify First Sex Chromosome Gene Involved in Meiosis and Male Infertility

Penn Researchers Identify First Sex Chromosome Gene Involved in Meiosis and Male Infertility

PHILADELPHIA -– A team of scientists led by University of Pennsylvania veterinary researchers have identified a gene, TEX11, located on the X chromosome, which when disrupted in mice renders the males sterile and reduces female fecundity. This is the first study of the genetic causes of infertility that links a particular sex chromosome meiosis-specific gene to sterility.

Jordan Reese

Agent Orange Chemical, Dioxin, Attacks the Mitochondria To Cause Cancer, Says Penn Research Team

Agent Orange Chemical, Dioxin, Attacks the Mitochondria To Cause Cancer, Says Penn Research Team

PHILADELPHIA— Researchers with the University of Pennsylvania School of Veterinary Medicine have demonstrated the process by which the cancer-causing chemical dioxin attacks the cellular machinery, disrupts normal cellular function and ultimately promotes tumor progression.

Jordan Reese

Penn Researchers Shine the Light of Venus to Learn How the Herpes Virus Invades Cells

Penn Researchers Shine the Light of Venus to Learn How the Herpes Virus Invades Cells

PHILADELPHIA -– University of Pennsylvania researchers have uncovered an important step in how herpes simplex virus, HSV-1, uses cooperating proteins found on its outer coat to gain entry into healthy cells and infect them. Further,the study’s authors say, they have demonstrated the effectiveness of monitoring these protein interactions using biomolecular complementation.

Jordan Reese

Researchers Led by Penn Vet Uncover the Delicate Protein Balance Behind the Immune System Response

Researchers Led by Penn Vet Uncover the Delicate Protein Balance Behind the Immune System Response

PHILADELPHIA -– A team of researchers from the University of Pennsylvania School of Veterinary Medicine has identified the protein interactions involved in the immune system process that fights infection yet, in certain inflammatory diseases, runs amok and attacks friendly tissue.

Jordan Reese

University of Pennsylvania Establishes Institute for Regenerative Medicine

University of Pennsylvania Establishes Institute for Regenerative Medicine

PHILADELPHIA -- The University of Pennsylvania is launching the Institute for Regenerative Medicine, a new cross-disciplinary endeavor to investigate and harness the therapeutic potential of stem cells in the treatment of cancer, diabetes, cardiovascular disease, degenerative diseases, wound healing and aging. Two renowned Penn scientists, Jonathan A. Epstein and Ralph L.

Jordan Reese

Penn Veterinarian Completes NIH Collaboration in First-Ever Sequencing of Domestic Cat Genome

Penn Veterinarian Completes NIH Collaboration in First-Ever Sequencing of Domestic Cat Genome

PHILADELPHIA  - A multi-center, National Institutes of Health-funded report that appears in the scientific journal Genome Research details the first assembly, annotation and comparative analysis of the domestic cat genome, Felis catus.  A University of Pennsylvania researcher is on the team.

Jordan Reese