Biology

Computer-generated antibiotics and biosensor Band-Aids

For Penn synthetic biologist César de la Fuente and his team, these concepts aren’t some far-off ideal. They’re projects already in progress, and they have huge real-world implications should they succeed.

Michele W. Berger

Where math meets biology

Through his research, Yoichiro Mori, the Calabi-Simons Visiting Professor of Mathematics and Biology, demonstrates how mathematical theories can provide insights into complex, living systems.

Erica K. Brockmeier

Reprogramming ant ‘soldiers’

A Penn study reveals the epigenetic pathway that controls social behavior in carpenter ants, finding that the ants reprogram up to five days after they hatch, while reprogramming was ineffective at the 10-day mark.

Penn Today Staff

Consuming alcohol leads to epigenetic changes in brain memory centers

What drives the biology behind alcohol cravings has remained largely unknown. A new Penn study shows how a byproduct of the alcohol breakdown produced mostly in the liver travels to the brain’s learning system and impacts behavior around environmental cues to drink.

Penn Today Staff

The science of sensations

To confront the ills of the opioid epidemic, scientists must develop a fundamental understanding of the biology of pain. Biologist Ishmail Abdus-Saboor’s work is setting the stage for screening alternative drugs and uncovering new pathways that an opioid-alternative could target.

Katherine Unger Baillie

Engineers solve the paradox of why tissue gets stiffer when compressed

Tissue gets stiffer when it’s compressed. That stiffening response is a long-standing biomedical paradox, as common sense dictates that when you push the ends of a string together, it loosens tension, rather than increasing it. New research explains the mechanical interplay between that fiber network and the cells it contains.

Penn Today Staff

Fruit flies’ microbiomes shape their evolution

In just five generations, an altered microbiome can lead to genome-wide evolution in fruit flies, according to new research led by Paul Schmidt and postdoc Seth Rudman of the School of Arts and Sciences.

Katherine Unger Baillie

A molecular ‘atlas’ of animal development

Scientists have studied the nematode worm Caenorhabditis elegans for decades, making essential contributions to basic science. In the latest milestone, a team uses cutting-edge technology to individually profile the genes expressed in more than 80,000 cells in a developing C. elegans embryo.

Katherine Unger Baillie

‘Information gerrymandering’ poses a threat to democratic decision making

Concern over fake news and online trolls is widespread and warranted, but researchers have identified another impediment to the free flow of information in social networks. The phenomenon, which they term “information gerrymandering,” arises from the structure of a social network and introduces bias into collective decisions.

Katherine Unger Baillie



In the News


Good Housekeeping

When is the best time to take L-theanine—morning or night?

According to Colleen Tewksbury of the School of Nursing, research suggests that L-theanine may help support stress management, sleep, and potentially weight management.

FULL STORY →



Stat

Is the flu shot market a slam dunk for mRNA vaccines? Experts aren’t so sure

Scott Hensley of the Perelman School of Medicine is working on a flu vaccine to provide protection against 20 subtypes of flu that may pose a pandemic threat in the future.

FULL STORY →



NPR

Thanks, Neanderthals: How our ancient relatives could help find new antibiotics

A study by César de la Fuente of the Perelman School of Medicine and colleagues used AI to recreate molecules from ancient humans that could be potential candidates for antimicrobial treatments.

FULL STORY →



NPR

Long COVID brain fog may originate in a surprising place, say scientists

A study by Christoph Thaiss and Maayan Levy of the Perelman School of Medicine and colleagues finds that long COVID’s neurological symptoms, like brain fog, memory loss, and fatigue, may stem from serotonin reduction.

FULL STORY →



Time

Long COVID research is in its ‘most hopeful’ phase yet

A study by Christoph Thaiss and Maayan Levy of the Perelman School of Medicine and colleagues suggests that serotonin could be a target for long COVID treatment.

FULL STORY →



ScienceAlert

A crucial pattern behind long COVID may have been identified

A study by Christoph Thaiss and Maayan Levy of the Perelman School of Medicine and colleagues suggests that several current hypotheses for the pathophysiology of long COVID are linked by a single pathway that is connected by serotonin reduction.

FULL STORY →